Paraganglion of the prostate gland: an uncommon mimic of prostate cancer in needle biopsies

Histopathology (Impact Factor: 3.45). 08/2005; 47(1):114-5. DOI: 10.1111/j.1365-2559.2005.02043.x
Source: PubMed
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    ABSTRACT: This chapter provides a practical overview of ­frequently used markers in the diagnosis and differential diagnosis of both common and rare neoplasms of prostate gland with a specific focus on adenocarcinoma and its mimickers. The chapter contains 41 questions; each question is addressed with a table, concise note, and representative pictures if applicable. In addition to the literature review, the authors have included their own experience and tested numerous antibodies reported in the literature. The most effective diagnostic panels of antibodies have been ­recommended for many entities, such as CK7, PAX2, and MUC6 being suggested as the best diagnostic panel for distinguishing seminal vesicles from prostatic ductal adenocarcinoma and high-grade prostatic intraepithelial neoplasia. Furthermore, immunophenotypes of normal prostate and seminal vesicles have been described, which tend to be neglected in the literature. KeywordsProstatic adenocarcinoma-P504S (AMACR)-PSA-PAX2-PIN4 (triple stain)
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    ABSTRACT: Paraganglia are an uncommon but previously reported finding in the genitourinary system. Recognition of this entity in the prostate is important in distinguishing it from prostatic adenocarcinoma. In this series, 1230 radical prostectomy specimens were examined for the presence of paraganglia, and a total of 57 cases (4.5%) were found to contain paraganglia. The majority of paraganglia were extraprostatic and could easily mimic extension of prostatic adenocarcinoma into extraprostatic tissue. It is important to recognize paraganglia, particularly when they are extraprostatic and could confer a falsely higher tumor stage to the patient. The paraganglia demonstrated characteristic histology, and immunohistochemistry was supportive when enough tissue was available. No association between patient age and frequency of paraganglia was found.
    International Journal of Surgical Pathology 07/2011; 19(6):772-4. DOI:10.1177/1066896911414567 · 0.95 Impact Factor
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    ABSTRACT: The spectrum of morphology in non-neoplastic prostate includes lesions of prostatic epithelial origin, the most common being atrophy, including partial atrophy, adenosis (atypical adenomatous hyperplasia), basal cell hyperplasia and crowded benign glands, as well as those of non-prostatic origin, such as seminal vesicle epithelium. These lesions often mimic lower-grade prostatic adenocarcinoma whereas others, such as granulomatous prostatitis, for example, are in the differential diagnosis of adenocarcinoma, Gleason grades 4 or 5. Diagnostic awareness of the salient histomorphological and relevant immunohistochemical features of these prostatic pseudoneoplasms is critical to avoid rendering false positive diagnoses of malignancy.
    Histopathology 01/2012; 60(1):41-58. DOI:10.1111/j.1365-2559.2011.04000.x · 3.45 Impact Factor