Double-blind prospective comparative trial between foamed and liquid polidocanol and sodium tetradecyl sulfate in the treatment of varicose and telangiectatic leg veins.

Dermatology/Cosmetic Laser Associates of La Jolla, Inc., La Jolla, California 92037, USA.
Dermatologic Surgery (Impact Factor: 1.56). 06/2005; 31(6):631-5; discussion 635. DOI: 10.1111/j.1524-4725.2005.31602
Source: PubMed

ABSTRACT Twenty subjects were treated with either polidocanol (POL) or sodium tetradecyl sulfate (STS) to compare the efficacy and adverse sequelae of each agent.
To determine the safety and efficacy of two widely used sclerosing agents.
After the exclusion of saphenofemoral junction incompetency, each subject's leg veins were categorized by size (< 1, 1-3, and 3-6 mm in diameter). Each leg was then randomized to be treated with 0.5%, 1%, or 1% foam of POL or 0.25%, 0.5%, or 0.5% foam of STS according to vein size. An independent panel of four physicians, blinded to treatment, performed randomized photographic evaluations obtained pretreatment and 12 weeks post-treatment. Subject satisfaction index and overall clinical improvement assessment were also obtained.
An average 83% improvement was noted for all vein sizes in all subjects with both POL and STS after a single treatment. Subjects were satisfied with treatment, regardless of the sclerosing agent used or the vein size treated. There was no statistically significant difference in adverse effects between each group.
Both POL and STS are safe and effective sclerosing agents in the treatment of varicose and telangiectatic leg veins. Both are very tolerable and demonstrate similar post-treatment sequelae.

1 Follower
  • [Show abstract] [Hide abstract]
    ABSTRACT: Abstract Introduction: Telangiectasias represent an esthetic problem. Sclerotherapy, laser and radiowave coagulation are established methods of treatment. The aim of the treatment is a cosmetic improvement in the leg appearance. Aim: To define which method provides best results in lower extremity telangiectasias treatment and also to determine which method is most comfortable for the patient. Materials and methods: Thirty female volunteers, ages 30-66 years (mean 49 years), were included in the research, with telangiectasias in the thigh measuring 0,1 to 2 mm in diameter, and skin phototype according to Fitzpatrick I-IV. Three rectangular areas 3 × 5 cm, were marked on the thigh, with nearly same pattern and appearance of telangiectasias in each field. In each rectangle, only one session of sclerotherapy, laser, and radiowave coagulation were performed, respectively. It is completely documented with the digital camera prior to the therapy and 3 months after the treatment. At the end of the study, three blinded experts graded leg telangiectasias for clearance using obtained digital images. Patients were also required to describe the sense of pain during each procedure as minimal, mild, or strong. Chi-square test was used for statistical data processing. Results: After 3 months period, there was a high statistical significant difference among methods of treatment (χ(2) = 45.492, p < 0.01). The most efficient was sclerotherapy. Also there was a high statistical significant difference (χ(2) test = 30.549, p < 0.01) among levels of pain experienced by patients in the study. Minimal sense of pain was associated with sclerotherapy. Conclusion: Our study revealed that the most efficient method in terms of telangiectasias clearance is sclerotherapy. It also showed that most comfortable method for the patient is sclerotherapy, since it produces minimal pain during the procedure. It can be concluded that sclerotherapy is a successful method in treating lower extremity telangiectasias leaving both, patient and physician content.
    Journal of Cosmetic and Laser Therapy 10/2012; 14(5):239-42. DOI:10.3109/14764172.2012.723806 · 1.11 Impact Factor
  • Source
    Jornal Vascular Brasileiro 01/2006; 5(1). DOI:10.1590/S1677-54492006000100010
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective To compare the efficacy and adverse effects of endovenous foam sclerotherapy (EFS) and liquid sclerotherapy (ELS) using a microcatheter for the treatment of varicose tributaries. Materials and Methods From December 2007 to January 2009, patients with venous reflux in the saphenous vein were enrolled. The foam or liquid sclerosant was injected through a microcatheter just before endovenous laser ablation (EVLA). Patients were evaluated for the technical success, clinical success, and procedure-related complications during the procedure and follow-up visits. Results A total of 94 limbs were included: 48 limbs (great saphenous vein [GSV], 35; small saphenous vein [SSV], 13) were managed using EFS and EVLA (foam group; FG), and 46 limbs (GSV, 37; SSV, 9) were treated by ELS and EVLA (liquid group; LG). Varicose tributaries demonstrated complete sclerosis in 92.7% with FG and in 71.8% with LG (p = 0.014). Bruising (78.7% in FG vs. 73.2% in LG, p > 0.05), pain or tenderness (75.6% in FG vs. 51.2% in LG, p = 0.0237) were noted. Hyperpigmentation (51.2% in FG vs. 46.2% in LG, p > 0.05) was found. Conclusion Endovenous foam sclerotherapy using a microcatheter is more effective than ELS for eliminating remnant varicose tributaries prior to EVLA. However, EFS is more commonly associated with local complications such as pain or tenderness than ELS. Furthermore, both techniques seem to prolong the duration of hyperpigmentation along with higher costs.
    Korean journal of radiology: official journal of the Korean Radiological Society 07/2014; 15(4):481-7. DOI:10.3348/kjr.2014.15.4.481 · 1.81 Impact Factor

Full-text (2 Sources)

Available from
May 17, 2014