Article
Socioeconomic position and self-rated health: the contribution of childhood socioeconomic circumstances, adult socioeconomic status, and material resources.
Department of Public Health, P.O. Box 41, 00014, University of Helsinki, Finland.
American Journal of Public Health (impact factor:
3.93).
09/2005;
95(8):1403-9.
DOI:10.2105/AJPH.2004.047969
pp.1403-9
Source: PubMed
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Article: Income, occupational position, qualification and health inequalities--competing risks? (comparing indicators of social status).
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ABSTRACT: The debate on health inequalities has shifted from the consequences of occupational position, as expressed in the Registrar General's classification, to consequences of material living conditions. This change in interest occurred without comparative analyses of different sources of health inequalities. Thus this study investigated the relative contribution of "material resources" (income), "qualification" and "occupational position" for explaining social differentials in mortality. Analyses were performed with records from a statutory health insurance in West Germany. The analyses were performed with data of 84,814 employed men and women between 25 and 65 years of age who were insured between 1987 and 1995 for at least 150 days. The three indicators were statistically associated, but not strong enough to warrant the conclusion that they share the same empirical content. The relative risk (hazard rate) for income by controlling for occupational position and gender for the highest as compared with the lowest category was 1.99 (95% CI 1.66, 2.39). The corresponding relative risk for income by controlling for qualification and gender was 2.03 (95% CI 1.68, 2.46). In both multivariate analyses, the effects of occupational position and qualification were no longer interpretable because of large confidence intervals. In sum, income related relative mortality risks were the comparably highest, while qualification and occupational position were no longer substantial. The results emphasise the present discussion on the consequences of material living conditions. Income on the one hand and qualification and occupational position on the other are largely independent. Mortality related effects of income override those of the other socioeconomic status indicators. However, seen in a time perspective, qualification may still have a placement function at least for the first occupational position.Journal of Epidemiology & Community Health 05/2000; 54(4):299-305. · 3.19 Impact Factor -
Article: Influence of renal function on the steady-state pharmacokinetics of the antiarrhythmic propafenone and its phase I and phase II metabolites.
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ABSTRACT: The aim of this study was to investigate the disposition of propafenone and its Phase I and II metabolites in relation to kidney function under steady-state conditions. The mechanism of the renal handling of propafenone glucuronides (filtration, secretion) was also examined. Racemic (R/S) propafenone was administered to 7 young volunteers, to 5 older patients with a normal glomerular filtration rate and to 4 patients with chronic renal failure. No difference was found in the plasma concentrations of propafenone and 5-hydroxypropafenone between the three groups. The propafenone glucuronide (PPFG) concentration was elevated in the older compared to the younger subjects (S-PPFG: 544 vs. 222 nmol.ml-1.mol-1; R-PPFG: 576 vs. 304 nmol.ml-1.mol-1). Although Glomerular filtration rate did not differ, the renal clearance of propafenone glucuronides was reduced in the former group, which could be attributed to their impaired renal secretion. A dramatic increase in propafenone glucuronide concentration was observed in the patients with renal failure (S-PPFG: 2783 nmol.ml-1.mol-1; R-PPFG: 7340 nmol.ml-1.mol-1). In summary, the disposition of propafenone and of its active metabolite 5-hydroxypropafenone was not affected by kidney dysfunction, indicating that no dose adjustment is necessary in patients with renal failure. The accumulation of drug glucuronides in older patients with apparently normal kidney function should be taken into account as a possible factor modifying drug therapy.European Journal of Clinical Pharmacology 02/1995; 48(3-4):279-83. · 2.85 Impact Factor
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Keywords
67% response rate
7 socioeconomic indicators
adult socioeconomic position
adulthood economic difficulties
Childhood economic difficulties
childhood socioeconomic circumstances
clear associations
consistent associations
conventional socioeconomic indicators
current material resources
Home ownership
household income
middle-aged adults
respondent's own education
respondents' own education
self-rated health
sequential logistic regression models
socioeconomic indicator
socioeconomic indicators
socioeconomic inequalities