Article

Mirtazapine in drug-induced excessive sweating.

University Department for Adult Psychiatrie, Lausanne, Switzerland.
European Journal of Clinical Pharmacology (Impact Factor: 2.7). 09/2005; 61(7):543-4. DOI: 10.1007/s00228-005-0956-z
Source: PubMed

ABSTRACT Excessive sweating is a well-known side effect of a selective serotonin reuptake inhibitor treatment, but little is known about the impact of sweating on treatment discontinuation or the general quality of life of patients. In this case report, we present a patient suffering from excessive sweating induced by escitalopram. When mirtazapine was administered as an additional treatment, a dose-dependent reduction of drug-induced excessive sweating was observed. Taking into account the particular serotonin antagonistic properties of mirtazapine, its eventual influence on the regulation of body temperature and diaphoresis in the central nervous system is discussed.

0 Followers
 · 
154 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Much of primary care involves helping patients manage symptoms. Nighttime sweating is a symptom linked to menopause, malignancies, autoimmune diseases, and infections. However, in primary care settings, night sweats are commonly reported by persons without these conditions. We conducted a literature review, focusing on questions about definition, mechanisms, incidence/prevalence, measurement, clinical causes, evaluation, treatment, and prognosis. We limited our search to English language studies of adult humans published since 1966. Because studies of estrogen and androgen deficiency states had been reviewed by others, we excluded them. Search criteria were developed for each question. Publications meeting criteria were reviewed by the first 2 authors and consensus was reached through discussion. Prevalence estimates ranged from 10% among older primary care patients to 60% among women on an obstetrics inpatient unit. Life expectancy of primary care patients reporting night sweats did not appear to be reduced. Although many clinical causes have been suggested, most are not well supported. Algorithmic approaches to evaluation are not evidence-based. Alpha adrenergic blockers may reduce night sweats in patients taking serotonin reuptake inhibitors. Thalidomide and thioridazine may benefit some terminal cancer patients with night sweats. The symptom, night sweats, appears to be nonspecific. Many questions about causation, evaluation, and management remain unanswered.
    The Journal of the American Board of Family Medicine 11/2012; 25(6):878-93. DOI:10.3122/jabfm.2012.06.120033 · 1.85 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: There are a variety of noradrenergic antidepressants available, most of which act by inhibiting neuronal noradrenaline re-uptake, although few drugs are specific for this action. Where drugs have numerous actions the adverse effects of noradrenaline reuptake may be difficult to isolate, although in this respect the adverse effects of reboxetine, a specific noradrenaline re-uptake inhibitor, are illuminating. Noradrenergic antidepressants typically cause minor changes in blood and heart rate, sweating and insomnia. Other pharmacological actions shown by non-specific antidepressants may act to worsen or mitigate these adverse effects. Noradrenergic drugs are less likely than selective serotonin reuptake inhibitors (SSRIs) to cause sexual dysfunction but more likely to cause urinary hesitancy. Doubts remain over the relative propensity for antidepressants with different modes of action to cause diabetes and hyponatraemia. Noradrenergic actions do not seem to confer a risk of death in overdose.
    Journal of Psychopharmacology 06/2013; 27:732-739. DOI:10.1177/0269881113492027 · 2.81 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Objective Several small published case reports have suggested that selective serotonin reuptake inhibitors (SSRIs) can cause night sweats. The purpose of this study was to investigate this possibility further and to explore possible associations between night sweats and other commonly prescribed medications. Design Cross-sectional, secondary data analysis. Setting Data were obtained during the Oklahoma Longitudinal Assessment of the Health Outcomes of Mature Adults, a longitudinal cohort study carried out in the Oklahoma Physicians Resource/Research Network. Participants 413 adult primary care patients aged 65-94 years. Interventions Current regular use of one of 35 classes of medication. Main Outcome Measures At least moderate night sweats during the prior month. Results A total of 38 (9.2 %) reported night sweats. Age, gender, body mass index, and total number of medications taken regularly were not associated with night sweats. After adjusting for age and gender, SSRIs (odds ratio [OR] 3.01; 95 % confidence interval [CI] 1.26-7.19), angiotensin receptor blockers (ARBs) (OR 3.44; 95 % CI 1.36-8.69), and thyroid hormone supplements (OR 2.53; 95 % CI 1.24-5.15) were the only classes of medications associated with night sweats. Conclusions Use of SSRIs may well be associated with night sweats in older patients. Associations found between night sweats and ARBs and thyroid supplements warrant further study.
    Drugs - Real World Outcomes 03/2015; 2(1). DOI:10.1007/s40801-015-0007-8