A Case of Esophageal Stricture Due to Metastatic Breast Cancer Diagnosed by Endoscopic Mucosal Resection

Department of Gastroenterology, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi, Kawachi, Tochigi 329-0498, Japan.
Japanese Journal of Clinical Oncology (Impact Factor: 2.02). 09/2005; 35(8):483-6. DOI: 10.1093/jjco/hyi123
Source: PubMed


Metastasis of breast cancer to the esophagus has been reported but is rare. It is often difficult to diagnose metastases of breast cancer to the esophagus because they are often located in the submucosa and covered with normal mucosa. Although several methods have been reported in order to obtain specimens for pathological diagnosis, the adverse effects including bleeding and perforation were considerable problems. We report a case of a patient with esophageal stricture due to metastatic breast cancer to the esophagus. Pathological diagnosis was successfully obtained using endoscopic mucosal resection of the esophagus.

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Available from: Yasuo Hozumi, Jan 08, 2014
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    • "Autopsy studies suggest an incidence rate of 3–6% of metastasis to the esophagus in patients dying of any type of cancer [1, 2]. Several case reports in the literature have documented metastasis to the esophagus from a variety of primary tumor sites such as breast [1, 3, 4, 5, 6], prostate [7], lung [1, 8, 9], liver [10], ovary [11], kidney [12] and rectum [13], with breast and lung being the most common. In addition, esophageal metastasis from colon cancer has also been described in one case who developed dysphagia due to esophageal stricture, which was successfully treated with surgical bypass and endoscopic prosthesis [14]. "
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    ABSTRACT: We present here the rare clinical case of a 44-year-old gentleman with metastasis from colon carcinoma to the esophagus presenting with multiple nodules and dysphagia, which was successfully managed with systemic chemotherapy. The patient presented at our institution with 3-month history of dysphagia almost 4 years after being operated for stage III carcinoma in the sigmoid colon. Endoscopic findings showed multiple nodules at the gastroesophageal junction and mid esophagus. Histological features and immunostains confirmed the diagnosis of metastatic colon carcinoma. Because of evidence of extensive metastatic disease in the spine and liver requiring systemic therapy, the patient was treated with chemotherapy with irinotecan and cetuximab, with subsequent improvement in tumor markers, liver metastasis and symptoms of dysphagia. Even though repeat endoscopy showed no improvement in esophageal nodules, the overall response to chemotherapy was positive. In conclusion, we present a very rare, previously unreported case of metastases from colon cancer to the esophagus presenting as non-obstructive nodules and dysphagia that responded to systemic chemotherapy.
    Case Reports in Gastroenterology 07/2012; 6(2):484-8. DOI:10.1159/000341587
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    ABSTRACT: A case of esophageal metastasis from a breast carcinoma is presented. Location was, as usual, midesophageal. The interval of time between breast carcinoma and the onset of esophageal symptoms was rather long. Barium swallow examination enabled correct diagnosis, whereas several series of superficial endoscopical biopsies were negative. Diagnosis was confirmed by deep endoscopical biopsy.
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