Breast Cancer Detection Based on Incremental Biochemical and Physiological Properties of Breast Cancers

University of Pennsylvania, Department of Biochemistry, Philadelphia, 19104-6059, USA.
Academic Radiology (Impact Factor: 2.08). 09/2005; 12(8):925-33. DOI: 10.1016/j.acra.2005.04.016
Source: PubMed

ABSTRACT To demonstrate that near-infrared spectroscopy would achieve sufficient sensitivity and specificity in human breast cancer to reach ROC/AUC values in the 90s and yet to warn of the potential liabilities of introduction of a novel technology in this field.
116 subjects from two nations (44 were cancer-verified by biopsy and histopathology) were reviewed. NIR spectroscopy of total hemoglobin and its relative oxygenation were monitored in breast cancers and compared to their contralateral breast in a 2D nomogram for diagnostic evaluation. A novel handheld NIR breast cancer detector pad with a 3-wavelength LED and 8 detectors with 4 cm separation between source and detectors was placed on the subject's breast. The method is convenient, rapid, and safe and has achieved high patient compliance with minimal patient apprehension of compression, confinement, or radioactivity.
The absorbance increments of the cancerous region are referred to the mirror image location on the contralateral breast. The two metrics are increased hemoglobin concentration due to angiogenesis and decreased hemoglobin saturation due to hypermetabolism of the cancer. The 2D nomogram display of these two metrics shows Zone 1 contains verified cancers and Zone 2 contains noncancers. ROC evaluation of the nomogram gives 95% AUC for the two sites, Philadelphia and Leipzig.
A simple, economical breast cancer detector has achieved high patient compliance and a high ROC/AUC score for a population which involved a range of tumors down to and including those of 0.8-1 cm in diameter.

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Available from: Brian Czerniecki, Aug 29, 2015
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    • "In this study, the goal is to increase the lesion visibility in DOT by combining fluorescence and optical absorption data at the voxel level in one single graph, a scatterplot. This concept was introduced by Chance et al. in optical imaging of breast cancer [11]. They plotted the mean percentage of oxygen desaturation of blood versus the mean blood volume of their patients into a graph. "
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    Biomedical Optics Express 04/2011; 2(4):1007-20. DOI:10.1364/BOE.2.001007 · 3.50 Impact Factor
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    • "Until now, studies have focused on using the intrinsic optical properties of the breast to visualize lesions without the use of fluorescent contrast agents. These studies described higher absorption for carcinomas than for the surrounding parenchyma due to increased blood content associated with angiogenesis [3–11]. However, intrinsic contrast alone is probably not sensitive enough for (early) lesion detection [12]. "
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    • "The utility of non-invasive imaging of the tissue oxygenation by multi-band near-infrared (NIR) light has been recognized for decades. The distinctly different spectra of hemoglobin absorption of the NIR light when being oxygenated and deoxygenated have enabled finding lesions of angiogenesis or altered oxygenation indicating malignant changes [1] [2]. Studies on prostate cancer have found a correlation between the cancer and increased micro-vessel density [3]. "
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