This study was performed to evaluate the effect of individualized diet challenges consisting of allergen foods on disease activity in rheumatoid arthritis (RA) patients. Twenty patients with positive skin prick test (SPT) response for food extracts and 20 with negative SPT response were included. All patients were instructed to restrict the most common allergen foods during 12 days and then assigned into two groups according to SPT results. Food challenges were performed with all of the allergen foods in prick test positive group (PTPG) and with corn and rice in prick test negative group (PTNG) during 12 days. Allergen foods were then eliminated from PTPG patients' diet, while corn and rice were removed in PTNG. Clinical evaluations were performed after fasting (baseline), at the end of the challenge phase and reelimination phase. Stiffness, pain, physician's and patient's global assessment of disease activity, health assessment questionnaire (HAQ), Ritchie's index, serum amyloid A protein, erythrocyte sedimentation rate and C-reactive protein were determined. All of the disease variables, except HAQ, were increased with food challenges in PTPG. In PTNG, no significant change was observed in any of the variables except pain (P<0.05) and patient's global assessment (P<0.05). Our results showed that the individualized dietary manipulations may effect the disease activity for selected RA patients.
[Show abstract][Hide abstract] ABSTRACT: A review of the effect of diets for people with rheumatoid arthritis was conducted by researchers in the Cochrane Collaboration. After searching for all relevant studies, they found 15 studies done by other researchers. Their findings are summarised below. What is rheumatoid arthritis and what diets have been tried? Rheumatoid arthritis is a disease in which the body's immune system attacks the lining of the joints. Usually, the joints of the hands and feet are affected first. Joints will become swollen, stiff and painful. There is no cure for RA at present, so treatments aim to relieve pain and stiffness, and improve the ability to move. To improve symptoms, some people have tried to change what they eat by following a wide variety of special diets. Some people will try to not eat anything for 7 to 10 days to see if it makes a difference. But usually people will try to limit or increase only certain foods. The most common diets tried are vegetarian or vegan, Mediterranean, 'elemental' , or elimination diets. Vegan diets do not include meat, fish, eggs and milk products, while some vegetarian diets allow eggs and milk. Mediterranean diets usually include a small amount of meat, more fish, more fruits and vegetables and olive oil. Elemental diets are usually liquid diets that contain nutrients that are broken down to make digestion easier. Elimination diets are used to find foods that might be the cause of symptoms. People usually eliminate foods they think are causing symptoms, and then add in the foods one at a time and see which ones cause symptoms. What the research says It is uncertain whether diets improve pain, stiffness and the ability to move better. Instead, diets may be difficult to stick to, and people may lose weight on these diets even though they did not plan to. - people who follow special diets may lose 3 kg (6 ½ pounds) more than people who do not follow special diets, even though they did not plan to.
[Show abstract][Hide abstract] ABSTRACT: Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by chronic inflammation and joint destruction. In this study, we investigated whether dietary supplementation with alpha lipoic acid (ALA) suppresses collagen-induced arthritis (CIA) in mice. Mice were randomly divided into three groups: (1) a control CIA group was fed a normal diet, (2) a CIA group was fed a 0.1% ALA diet (average ALA intake of 160 mg/kg/day), and (3) a CIA group was fed a 0.5% ALA diet (average ALA intake of 800 mg/kg/day). The ALA-fed mice showed a decreased incidence and severity of arthritis compared to the normal diet group. Radiographic findings revealed a dramatic decrease in bone destruction, and histological findings showed extensively suppressed pathological changes in the ALA-fed mice. The ALA-fed mice exhibited inhibited generation of tartrate resistant acid phosphatase (TRAP)-positive osteoclasts in vivo. Additionally, ALA-fed mice reduced production of various proinflammatory cytokines and the soluble receptor activator of NF-κB ligand (sRANKL) in the joint tissues and the sera. In conclusion, dietary supplementation with ALA attenuated inflammatory responses and bone destruction in CIA mice.
Rheumatology International 05/2010; 31(12):1583-90. DOI:10.1007/s00296-010-1505-3 · 1.52 Impact Factor
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