Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
Robert A. Sweet, MD
eRA COMMONS USER NAME
Associate Professor of Psychiatry
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
FIELD OF STUDY
Rensselaer Polytechnic Institute, Troy, NY
Albany Medical College, NY
University of Maryland, School of Medicine,
MD 1984 Medicine
Positions and Honors
1984 Alpha Omega Alpha, University of Maryland School of Medicine
1984-88 Residency, Department of Psychiatry, Albany Medical Center Hospital, Albany, NY
1988-89 Instructor of Clinical Psychiatry, Albany Medical College, Albany, NY
1989-90 Assistant Professor of Clinical Psychiatry, Albany Medical College, Albany, NY
1990-95 Assistant Professor of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA
1994 Scientist Development Award for Clinicians, National Institute of Mental Health
1996- Associate Professor of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA
1996- Vice Chairman, Institutional Review Board, University of Pittsburgh, Pittsburgh, PA
1998-2005 Chief Psychiatrist, Geriatric Services, Western Psychiatric Institute and Clinic, Pittsburgh, PA
2001 First Place, Research Award in Psychogeriatrics, International Psychogeriatric Association
2001 Founding Member, International College of Geriatric Psychoneuropharmacology
2002 Turken Lectureship, Alzheimer’s Association of Los Angeles
2005 Annual Mentorship Award, Department of Psychiatry, Western Psychiatric Institute and Clinic
2006 Co-Associate Director for Research, Mental Illness Research, Education, and Clinical Center, VA
Pittsburgh Healthcare System
Selected Publications (From a total of 91 peer reviewed)
Sweet RAC, Bergen SE, Sun Z, Sampson AR, Lewis DA. Anatomical Evidence of Impaired Feedforward
Auditory Processing in Schizophrenia. Biological Psychiatry, available online 2006 Nov 20. PMID: 17123477
Konopaske GT, Sweet RA, Wu Q, Sampson A, Lewis DA. Regional specificity of chandelier neuron axon
terminal alterations in schizophrenia. Neuroscience, 2006;138(1):189-196.
Sweet RAC, Dorph-Petersen K-A, Lewis DA. Mapping auditory core, lateral belt, and parabelt cortices in the
human superior temporal gyrus. Journal of Comparative Neurology, 491(3): 270-89, Oct 2005.
Go RC, Perry RT, Wiener H, Bassett SS, Blacker D, Devlin B, Sweet RA. Neuregulin-1 polymorphism in late
onset Alzheimer's disease families with psychoses. Am J Med Genet B Neuropsychiatr Genet. 2005 Nov
Sweet RA, Devlin B, Pollock BG, Sukonick DL, Kastango KB, Bacanu SA, Chowdari KV, Dekosky ST, Ferrell
RE. Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease. Mol
Psychiatry. 2005 Nov;10(11):1026-36.
Eror EA, Lopez OL, Dekosky ST, Sweet RA. Alzheimer disease subjects with psychosis have increased
schizotypal symptoms before dementia onset. Biol Psychiatry. 2005 Aug 15;58(4):325-30.
Bacanu SA, Devlin B, Chowdari KV, Dekosky ST, Nimgaonkar VL, Sweet RA. Heritability of Psychosis in
Alzheimer Disease. Am J Geriatr Psychiatry, 2005 Jul;13(7):624-7.
Sweet RAC; Hamilton RL, Butters MA, Mulsant BH, Pollock BG, Lewis DA, Lopez OL, DeKosky ST, Reynolds
CF III. Neuropathologic correlates of late-onset major depression. Neuropsychopharmacology, 29(12):2242-
Sweet RAC, Bergen SE, Sun Z, Sampson AR, Pierri JN, Lewis DA. Pyramidal cell size reduction in
schizophrenia: evidence for involvement of auditory feedforward circuits. Biol Psychiatry, 2004;55:1128-1137.
Perez-Madrinan G, Cook SE, Saxton JA, Miyahara S, Lopez OL, Kaufer DI, Aizenstein HJ, DeKosky ST,
Sweet RAC. Alzheimer Disease with psychosis: Excess cognitive impairment is restricted to the
misidentification subtype. Am J Geriatr Psychiatry, 12:449-456, 2004.
Sweet RAC, Pierri JN, Auh S, Sampson AR, Lewis DA. Reduced pyramidal cell somal volume in auditory
association cortex of subjects with schizophrenia. Neuropsychopharmacology, 28(3):599-609, 2003.
Lewis DA, Glantz L, Pierri JN, Sweet RA. Altered cortical glutamate neurotransmission in schizophrenia:
Evidence from morphological studies of pyramidal neurons, Ann N Y Acad Sci. 2003 Nov;1003:102-12.
DeKosky ST, Ikonomovic MD, Wang X, Farlow M, Wisniewski S, Lopez OL, Becker JT, Saxton J, Klunk WE,
Sweet R, Kaufer DI, Kamboh MI. Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's
disease: Correlation with cognitive impairment. Ann Neurol, 53(1): 81-90, 2003.
Cook SE, Miyahara S, Bacanu SA, Perez G, Lopez OL, Kaufer DI, Nimgaonkar VL, Wisniewski SR, DeKosky
ST, Sweet RAC. Psychotic Symptoms in Alzheimer Disease. Evidence for Subtypes. Am J Geriatr Psychiatry.
11(4): 406-413, 2003.
Sweet RAC, Panchalingam K, Pettegrew JW, McClure RJ, Hamilton RL, Lopez OL, Kaufer DI, DeKosky ST,
Klunk WE. Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess
neuronal and membrane phospholipid pathology. Neurobiol Aging, 23: 547-553, 2002.
Bacanu SA, Devlin B, Chowdari KV, DeKosky ST, Nimgaonkar VL, Sweet RA. Linkage analysis of Alzheimer
disease with psychosis. Neurology, 59:118-120, 2002.
Sweet RA, Nimgaonkar VL, Devlin B, Lopez OL, DeKosky ST. Increased familial risk of the psychotic
phenotype of Alzheimer disease. Neurology, 58:907-911, 2002.
Sweet RA, Kamboh MI, Wisniewski SR, Lopez OL, Klunk WE, Kaufer DI, DeKosky ST. APOE and ACT
genotypes do not predict time to psychosis in Alzheimer disease. J Geriatr Psychiatry Neurol, 15:24-30, 2002.
McFarland C, Sweet RAC, DeKosky ST, Houck PR, Mulsant BH, Pollock BG, Reynolds CF. The
Establishment of a brain bank for the study of late life depression: a feasibility study of factors facilitating
consent. CNS Spectr, 7(11): 816-821, 2002.
Sweet RA, Pollock BG, Sukonick DL, Mulsant BH, Rosen J, Klunk WE, Kastango K, DeKosky ST. The 5-
HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in
Alzheimer disease. Int Psychogeriatr, 13(4) 401-409, 2001.
Sweet RA, Hamilton RL, Healy MT, Wisniewski SR, Henteleff R, Pollock BG, Lewis DA, DeKosky ST:
Alterations of striatal dopamine receptor binding in Alzheimer disease are associated with Lewy body
pathology and with antemortem psychosis. Arch Neurol, 58:466-472, 2001.
Sweet RAC, Henteleff RA, Meinert KA, DeMichele MA, Kirshner MA, Sorisio DA, Pollock BG. The
antipsychotic radioreceptor assay: a modification identifying selective receptor effects. Ther Drug Monit, 23(4):
Sweet RAC, Hamilton RL, Lopez OL, Klunk WE, Wisniewski SR, Kaufer DI, Healy MT, DeKosky ST. Psychotic
symptoms in Alzheimer’s disease are not associated with more severe neuropathologic features. Int
Psychogeriatr, 12(4): 547-558, 2000.
Sweet RA, Nimgaonkar VL, Kamboh M.I., Lopez OL, Zhang F, DeKosky ST: Dopamine receptor genetic
variation, psychosis, and aggression in Alzheimer disease. Arch Neurol, 55:1335-1340, 1998.
Mulsant BH, Stergiou A, Keshavan MS, Sweet RA, Rifai AH, Pasternak R, Zubenko GS. Schizophrenia in late-
life: A clinical study of elderly patients admitted to an acute care psychiatric hospital. Schizophrenia Bull, 19(4):
Ongoing Research Support
1 R01 AG027224 Sweet (PI)
Prediction of Psychosis in Alzheimer Disease
To analyze a highly probable set of psychosis candidate genes in combination with phenotypic information to
address several key questions regarding AD+P
1 R01 MH071533 Sweet (PI) 07/01/04 - 06/30/09
Auditory Corticocortical Circuits in Schizophrenia
This project will use unbiased stereologic methods in postmortem tissue to test the hypothesis that auditory
corticocortical feedforward circuits are selectively impaired in subjects with schizophrenia.
5 P50 MH45156 Lewis (Center Director) 07/01/03 - 06/30/08
Conte Center for the Neuroscience of Mental Disorders (CCNMD): Cortical Circuitry and Cognition in
This Center for the Neuroscience of Mental Disorders links a large group of investigators in a coordinated
series of studies designed to characterize the role of cortical dysfunction in the cognitive symptoms of
Human Brain Bank Core
The goal of the Human Brain Bank Core is to identify, recover, assess and distribute postmortem human
brain specimens from subjects with schizophrenia and matched normal control and nonschizophrenic
psychiatric comparison subjects. This Core provides the tissue specimens and clinical information for the
studies included in the eight projects included in the Center.
Project 1: Dysfunction of DLPRC Pyramidal Neurons in Schizophrenia: Morphology and Mechanisms
These studies are designed to study the role of dorsolateral prefrontal cortical pyramidal neurons and their
circuitry in the pathophysiology of schizophrenia.
5 P50 AG05133 DeKosky (Center Director) 07/01/05 - 03/31/10
The clinical core will perform clinical and research evaluations at the study entry and at annual follow-up of
patients with AD and related dementias and control subjects participant in the ADRC.
Role: Research Psychiatrist
1 U01 MH62565-01A2 Mulsant (PI) 09/06/02 - 05/31/07
Acute Pharmacotherapy of Unipolar Psychotic Depression
To compare the efficacy of combination pharmacotherapy for psychotic depression to monotherapy with the
same doses of an atypical antipsychotic. To determine whether the efficacy of combination treatment for PD is
lower in older than young adults.
Recently Completed Research Support
1 R21 MH066231 Sweet (PI) 07/01/02 - 06/30/04
Auditory Cortex: Regional Pathology in Schizophrenia
This project will determine whether 1) chemoarchitectonic criteria reliably parcellate human auditory cortex into
regions corresponding to the core, lateral belt and parabelt regions delineated in non-human primates, 2)
04/01/07 – 03/31/12
auditory lateral belt and parabelt, but not core, cortex volumes are reduced in subjects with schizophrenia, and
3) reduced deep layer 3 pyramidal cell mean somal volume in subjects with schizophrenia results from a shift
to smaller size of all cells and not from a change in cell number.
5 P50 AG05133 DeKosky (Center Director) 05/01/00 - 03/31/05
NIA Genetics Initiative Administrative Supplement
This supplement was provided to identify, recruit, and diagnostically characterize families with multiple
members affected by Late Onset AD, as part of a National Multicenter Initiative.
Role: Project PI
5 P50 AG05133 DeKosky (Center Director) 05/01/00 - 03/31/05
Molecular Pharmacology of Psychosis Risk in AD, ADRC- Project 4
The major goals of this project are to characterize the psychotic phenotype of AD, and to examine its
associations with variation in select serotonin and dopamine receptor genes.
Role: Project PI
3 P30 MH52247 S1 Reynolds, III (PI) 03/01/02 - 02/28/05
Administrative Supplement for Human Postmortem Brain Collection in Severe Mental Disorders
The aim is to establish a brain bank for late life mood disorders.
Role: Project PI
Collaborative Project Sweet (PI) 07/01/02 - 06/30/04
Genetics of Alzheimer Disease with Psychosis
To establish a collaborative consortium at the University of Pittsburgh, UAB, Duke and WUSL to recruit
affected sib-pairs with AD, behaviorally characterize subjects, and perform initial moderate throughput
genotyping with the goal of conducting linkage analyses.