Benign Müllerian Papilloma of Childhood

Department of Pathology, The Children's Hospital, Denver, Colorado 80218, USA.
Ultrastructural Pathology (Impact Factor: 1.08). 05/2005; 29(3-4):209-16. DOI: 10.1080/01913120590951211
Source: PubMed


Benign müllerian papilloma of the female reproductive tract is a rare childhood tumor that can easily be mistaken by those unfamiliar with the entity for botryoid rhabdomyosarcoma. Ultrastructural findings have been mentioned only in two individual case reports, and these both were issued many years ago. The aim of this update is to familiarize the reader with the clinical, light, and electron microscopic features associated with this distinctive entity, and thereby hopefully preclude the risk of making a serious diagnostic error. Two cases are illustrated, one very typical in its presentation and the other less so.

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    ABSTRACT: Müllerian papilloma is a rare benign tumor of the cervix and/or vagina that occurs predominantly in young children. The cytologic features of benign müllerian papilloma have never been described. We report for the first time, to our knowledge, the cytologic findings of a benign müllerian papilloma from the vaginal fluid specimen of a 15-mo-old girl using touch prep, ThinPrep, and cell block preparations. The deceptive cytologic features of a cellular specimen with complex papillary fronds composed of overlapping and crowded small hyperchromatic cells, with a high nuclear:cytoplasmic ratio, and feathering in this case resembled a malignant neoplasm. The clinical findings and cytomorphology of a benign müllerian papilloma can mimic those of malignant lesions of the female lower genital tract such as sarcoma botryoides and adenocarcinoma. An awareness of this entity and its potential to mimic these more aggressive neoplasms is essential for accurate diagnosis and to avoid over-treatment.
    Diagnostic Cytopathology 09/2007; 35(9):607-11. DOI:10.1002/dc.20712 · 1.12 Impact Factor
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    ABSTRACT: Background: This report presents a case of tubulo-villous adenoma in the vagina of a 39 old woman, which is considered as a rare case. Case: Gross examination revealed a polypoid tumor measuring 19x13x9 mm. Histologically cells lining the neoplastic tubulovillous glands were columnar with ovoid nuclei, and often stratified. Considerable amount of goblet cells were stained positive with HID/AB indicating the presence of sialomucin, which is considered to be colonic-like mucus. Conclusion: This case is considered worthy to be reported, in order to emphasize the possible origin of this rare condition and the need for careful follow-up.
    Zhonghua bing li xue za zhi Chinese journal of pathology 04/2009; 38(3):202. DOI:10.3760/cma.j.issn.0529-5807.2009.03.017
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    ABSTRACT: Vaginal bleeding is a rare occurrence in infancy and childhood. It is usually due to trauma, child abuse, foreign bodies, and rarely, a friable botryoid tumor. We discuss a case of a vaginal müllerian duct papilloma in a 2 year old infant that presented with vaginal bleeding. To our knowledge, this is the second case reported in the literature of a vaginal müllerian duct papilloma presenting in a toddler. This rare type of tumor has an excellent prognosis when completely excised. A 2-year-old female that presented with bloody spotting in the diaper was found to have a vaginal.
    Journal of pediatric and adolescent gynecology 08/2009; 22(5):e124-6. DOI:10.1016/j.jpag.2008.10.002 · 1.68 Impact Factor
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