Paget's disease of the glans penis secondary to transitional cell carcinoma of the bladder: A report of two cases and review of the literature

Department of Pathology, 12 de Octubre University Hospital, Avenida de Córdoba s/n, 28041 Madrid, Spain.
Journal of Cutaneous Pathology (Impact Factor: 1.58). 05/2004; 31(4):341-5. DOI: 10.1111/j.0303-6987.2004.0184.x
Source: PubMed


Extramammary Paget's disease of the glans penis secondary to transitional cell carcinoma (TCC) of the bladder is rare, with only a few cases reported in the literature. We report two new cases, one detected before diagnosing bladder TCC.
We describe the clinicopathologic features of two patients with intraepithelial spread of glans TCC and the histochemical and immunohistochemical features of the neoplasm.
Light microscopy detected intraepithelial proliferation of neoplastic, large, pale cells located predominantly in the basal and parabasal layers of the epithelium. The pagetoid cells showed positive cytoplasmic staining for mucosubstances and immunoreactivity for CK20. The previously reported cases are reviewed and the differential diagnosis is discussed.
As many benign and malignant glans lesions may be clinically similar, histologic study is necessary to correctly diagnose primary lesions and promptly detect underlying asymptomatic visceral malignancies initially presenting as Paget's disease.

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    • "Among bladder CIS cases, 12-16% involve pagetoid change.4,5 However, cases with pagetoid spread of UC to the skin are rare, and there have been only a few reports of UC of the bladder that spread to the skin, including the glans penis, urethral meatus, and vulva.6 In such cases, discrimination of a perineal pagetoid lesion of UC from primary extramammary Paget’s disease requires immunohistochemistry with antibodies against CK7, CK20, Mucin, PAS, CEA and GCDFP15.6-9 "
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    ABSTRACT: Patients with ostomy including urinary stoma often develop peristomal complications, especially skin damage. The patient in this case was a 69-year old female with a history of urothelial carcinoma of the bladder and left ureter who underwent transurethral resection of a bladder tumor, nephroureterectomy and cystectomy combined with ureterocutaneostomy. Later, she had recurrence of urothelial carcinoma in the remaining ureter that spread to the peristomal epidermis, with a skin appearance resembling Paget's disease. We report this case based on its clinical significance since we believe it is the first description of this condition in the literature.
    Rare tumors 07/2013; 5(3):e49. DOI:10.4081/rt.2013.e49

  • British Journal of Dermatology 10/2005; 153(3):677-9. DOI:10.1111/j.1365-2133.2005.06798.x · 4.28 Impact Factor
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    ABSTRACT: Paget's disease is an intra-epidermal adenocarcinoma seen over the nipple/areola (mammary Paget's disease) or in extramammary body zones, such as the anogenital and perineal skin and the axilla. Mammary and extramammary Paget's disease share many common clinicopathological features but also show several differences, namely, with regard to pathogenesis and association with underlying malignancies. Indeed, mammary Paget's disease is as a rule associated with an underlying breast carcinoma whereas association of extramammary Paget's disease with underlying (skin or visceral) malignancies occurs much less frequently. We review here the main clinicopathological and therapeutic features of mammary and extramammary Paget's disease.
    Journal of the European Academy of Dermatology and Venereology 06/2007; 21(5):581-90. DOI:10.1111/j.1468-3083.2007.02154.x · 2.83 Impact Factor
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