Sox proteins and neural crest development.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Seminars in Cell and Developmental Biology (Impact Factor: 5.97). 01/2006; 16(6):694-703. DOI: 10.1016/j.semcdb.2005.06.005
Source: PubMed

ABSTRACT Among the families of transcription factors expressed at the neural plate border in response to neural crest-inducing signals, Sox proteins have emerged as important players in regulating multiple aspects of neural crest development. Here, we summarize the expression of six Sox genes, namely Sox8, Sox9, Sox10, LSox5, Sox4 and Sox11, in neural crest progenitors and their derivatives, and review some aspects of their function pertaining to neural crest development in several species.

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