Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate.

Institute of Neuroimmunology, Neuroscience Research Center, Charité, University-Medicine, NWFZ 2680, Charité, 10098 Berlin, Germany.
Journal of Neuroimmunology (Impact Factor: 3.03). 11/2005; 167(1-2):204-9. DOI: 10.1016/j.jneuroim.2005.06.027
Source: PubMed

ABSTRACT Neuronal damage mediated by the TRAIL-system might be involved in the pathogenesis of neuroinflammatory diseases of the central nervous system. Here we used an investigator-independent approach to quantify TRAIL-mediated death of total CNS cells and neurons in a living human brain slice culture system, a model which is much closer to the in vivo situation than dissociated cell culture. We observed dose-dependent TRAIL-mediated death of both total human CNS cells and neurons, which was prevented by flupirtine-maleate, a centrally acting analgesic drug with proposed neuroprotective properties. Our data suggest flupirtine-maleate as an orally available neuroprotective approach in the course of neuroinflammation.

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