Article
Radiation induced osteogenic sarcoma of the maxilla.
Department of Oral and Maxillofacial Surgery, Government Dental College, Thiruvananthapuram, 695011, Kerala, India.
World Journal of Surgical Oncology (impact factor:
1.12).
08/2005;
3:49.
DOI:10.1186/1477-7819-3-49
pp.49
Source: PubMed
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Article: Osteosarcoma of the jaws. Analysis of 56 cases.
Cancer 04/1967; 20(3):377-91. · 4.77 Impact Factor -
Article: Osteosarcoma of the jaw.
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ABSTRACT: The records of 66 patients with osteosarcoma of the jaw were reviewed. The ages of the 42 males and 24 females ranged from 12 to 79 years (mean, 34.2 years). Swelling and pain, the most frequent presenting complaints, were noted an average of three months before the patient was seen by a physician. Fifty-one percent of the lesions involved the maxilla and 49% involved the mandible. The most common sites of involvement were the body of the mandible and the alveolar ridge of the maxilla. Radiologically, most of the lesions in the maxilla were osteoblastic (50%), whereas most of those in the mandible were osteolytic (43%). Chondroblastic osteosarcoma was the most frequent histologic type (48%) and was associated with the best survival rate (47%). Treatment included radical and local surgery with radiotherapy, chemotherapy, or various combinations. The recurrence rate for all treatment modalities was 70%. Patients treated by initial radical surgery had the best survival (80%). Survival decreased to 27% with local surgery. Of the 43 (65%) patients who died, most died with uncontrolled local disease; only four patients had documented distant metastasis, which involved lung, cervical lymph nodes, spinal column, and brain.Cancer 07/1983; 51(12):2311-6. · 4.77 Impact Factor -
Article: Improved outcomes in patients with osteogenic sarcoma of the head and neck.
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ABSTRACT: The current study reviews the authors' recent institutional experience in the treatment of osteosarcoma of the head and neck (OSHN). The clinical records of 44 patients who were treated between 1981 and 1998 for OSHN were reviewed retrospectively. Archived histologic material was reviewed and data were analyzed to identify factors predictive of disease control and survival. Outcomes were compared with a previously reported historic cohort treated at the study institution. Patients ranged in age from 6 to 64 years (median, 31 years). The mandible was the primary site in 18 patients (41%), the maxilla in 20 patients (45%), and the skull in 6 patients (14%). Surgery was employed in all 44 patients, neoadjuvant chemotherapy was administered in 30 patients (68%), and postoperative radiation therapy was given to 7 patients (16%). The surgical excision margins were positive in 13 patients (30%). High-grade lesions were reported in 50% patients and low-grade lesions were noted in 18% of patients (grade was not assessable in 32%). Histologic response was "unfavorable" in 22 of 30 patients (73%) who were treated with neoadjuvant chemotherapy. The 3-year overall, disease-specific, and recurrence-free survival rates were approximately 81%, 81%, and 73%, respectively (median follow-up of 41 months). Positive surgical margins were found to be the only significant predictor of worse disease-specific survival. Compared with the historical cohort, the current experience demonstrated an obvious improvement in the 5-year local control (35% vs. 78%), distant metastases (37% vs. 13%), and overall survival (23% vs. 70%). Negative surgical margins were found to be the only significant predictor of overall and disease-specific survival. The results of the current study represent a considerable improvement over the authors' previously published experience and compare favorably with the results reported in the literature.Cancer 11/2002; 95(7):1495-503. · 4.77 Impact Factor
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Keywords
adjuvant chemotherapy
buccal mucosa
jaw bones
malignant conditions
maxillary bone
radiation induced sarcoma
radiation treatment
rare occurrence
rarer
reradiation
squamous cell carcinoma
term complication