Article

Radiation induced osteogenic sarcoma of the maxilla

Department of Oral and Maxillofacial Surgery, Government Dental College, Thiruvananthapuram, 695011, Kerala, India.
World Journal of Surgical Oncology (Impact Factor: 1.2). 08/2005; 3:49. DOI: 10.1186/1477-7819-3-49
Source: PubMed

ABSTRACT Radiation induced sarcoma arise as a long term complication of radiation treatment for other benign or malignant conditions. They are of very rare occurrence in jaw bones and are even rarer in maxilla.
Here we report a case of radiation induced sarcoma in a patient treated for squamous cell carcinoma of buccal mucosa with radiation who developed osteosarcoma of maxillary bone after six years. The patient was treated successfully with surgery.
What should be the best treatment of radiation induced sarcoma is still debatable; however, surgery offers the best chance of cure. Role of reradiation and adjuvant chemotherapy needs to be further evaluated.

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    • "Surgery appears to offer the best chance of cure. However, as osteosarcoma metastasizes by the hematogenous route, there is rationale for the addition of adjuvant chemotherapy [4]. There have not been large studies to determine the effectiveness of various treatments for postirradiation osteosarcoma. "
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