Radiation induced osteogenic sarcoma of the maxilla

Department of Oral and Maxillofacial Surgery, Government Dental College, Thiruvananthapuram, 695011, Kerala, India.
World Journal of Surgical Oncology (Impact Factor: 1.2). 08/2005; 3:49. DOI: 10.1186/1477-7819-3-49
Source: PubMed

ABSTRACT Radiation induced sarcoma arise as a long term complication of radiation treatment for other benign or malignant conditions. They are of very rare occurrence in jaw bones and are even rarer in maxilla.
Here we report a case of radiation induced sarcoma in a patient treated for squamous cell carcinoma of buccal mucosa with radiation who developed osteosarcoma of maxillary bone after six years. The patient was treated successfully with surgery.
What should be the best treatment of radiation induced sarcoma is still debatable; however, surgery offers the best chance of cure. Role of reradiation and adjuvant chemotherapy needs to be further evaluated.

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    • "Surgery appears to offer the best chance of cure. However, as osteosarcoma metastasizes by the hematogenous route, there is rationale for the addition of adjuvant chemotherapy [4]. There have not been large studies to determine the effectiveness of various treatments for postirradiation osteosarcoma. "
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    ABSTRACT: Background. Radiation-induced sarcomas are well-known potential late sequelae of radiation therapy. They are of rare occurrence in jaw bones and are even rarer in the maxilla. Case report. We report a case of radiation-induced osteosarcoma involving the maxilla in a patient treated with radiotherapy for nasopharyngeal carcinoma 14 years ago. Despite neoadjuvant chemotherapy, surgical treatment could not be performed, and the patient received palliative chemotherapy. Conclusions. Radiation-induced osteosarcomas are aggressive and often elude early detection and timely intervention, rapidly leading to early demise of afflicted patients. Long-term patient follow-up and a high index of suspicion are crucial for timely intervention.
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    ABSTRACT: Radiation-induced sarcomas are well-known though uncommon potential late sequelae of radiation therapy. We report irradiation-induced osteosarcoma involving the maxilla following treatment of nasopharyngeal carcinoma in a 44-year-old man who presented with painful cheek swelling. Radiographs and computed tomography showed a large destructive lesion of the left maxilla. Diagnosis of osteosarcoma was confirmed by excision biopsy.
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