Endoscopic management of pediatric brain tumors.

Department of Neurological Surgery, Weill Medical College of Cornell University, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Neurosurgical FOCUS (Impact Factor: 2.14). 07/2005; 18(6A):E1. DOI: 10.3171/foc.2005.18.6.2
Source: PubMed

ABSTRACT Primary endoscopic procedures for children with intraventricular brain tumors include endoscopic tumor biopsy and endoscopic tumor removal. The simultaneous treatment of hydrocephalus with endoscopic third ventriculostomy (ETV) or endoscopic septostomy increases the appeal of a minimally invasive endoscopic approach.
Eighty-five patients who underwent endoscopic management of an intraventricular brain tumor were identified from a prospective database. Of these patients, 26 were younger than 21 years of age at the time of diagnosis. The surgical technique, its success rate, and patient outcome were assessed. Illustrative cases are used in this study to detail the procedure of endoscopic tumor biopsy and resection. Endoscopic tumor procedures were successful in 96% of cases (23 of 24 endoscopic tumor biopsy samples and both endoscopic tumor removals). Fourteen simultaneous procedures were performed to treat hydrocephalus successfully. There was no recognized morbidity from the surgical procedures.
Endoscopic surgery in children with intraventricular brain tumors is an effective and safe method for sampling of the lesion and, in select cases, its resection. This minimally invasive technique should be considered in situations in which the patient might thereby avoid a more conventional procedure, given the high rate of success and low morbidity associated with endoscopic management.

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    ABSTRACT: Aims. The aim of our research was to analyse the long-term results of thrombolysis and posterior resection of the first rib (RFR) in the treatment of primary subclavicular-axillary venous thrombosis (SAVT). Patients and methods. We carried out a retrospective review of 18 SAVT in 17 patients between February 1991 and September 2000: eight males and nine women with an average age of 32 (SD: 8.9) years. In 14 cases a locoregional thrombolysis was per- formed and in four cases it was not carried out because they presented SAVT with more than 2 weeks' evolution. The thrombosed segment was totally repermeabilised in eight cases (57%), partially in five (36%) and was not achieved in only one (7%). The first rib was resected by a transaxillary approach in six patients. All the patients were submitted to clinical follow-up and 13 of them were monitored by duplex. Results. The average follow-up was 28 (SD: 11.5) months. At the end of the follow-up, the patients who had not been submitted to thrombolysis or in whom it had not been effective were twice as likely to present oedema as those in whom thrombolysis had been effective; RR: 2.2; CI 95%: 1.35-13.34. All the patients who underwent surgery were asymptomatic and displayed a normal duplex. There were no major complications during the thrombolytic procedure or following the RFR. Conclusion. Thrombolysis offers excellent results in the treatment of SAVT. RFR helps to keep the procedure permeable and the morbidity rate low. (ANGIOLOGÍA 2002; 54: 370-80)
    Angiología 01/2002; 54(5).
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    ABSTRACT: BACKGROUND:: Controversy surrounds the fate of cyst remnants following endoscopic colloid cyst resection. OBJECTIVE:: Our study evaluated recurrence rates in patients with total endoscopic resection of colloid cysts versus those with coagulated cyst remnants. METHODS:: Sixty-five consecutive patients and 67 procedures for endoscopic resection of colloid cysts from 1995 to 2011 were reviewed. Degree of resection was based upon intra-operative assessment and post-operative MRI. Recurrence rates were compared between patients with complete resection versus coagulated cyst remnants. RESULTS:: Data analysis was performed on 56 patients and 58 procedures, with no follow-up in 9 patients. All patients had MR-defined complete resection. On intra-operative assessment, 9 procedures had coagulated remnants and 45 procedures had complete resection (4 data unknown). The overall recurrence rate was 6.89% (4/58), 33.3% (3/9) with cyst remnants and 2.2% (1/45) with total resection (p= 0.0124). Maximum follow-up was 144 months (mean = 40.4 mo). Mean follow-up was 66.0 months for cyst remnant cases, and 33.5 months for totally resected cases. There was no mortality or permanent morbidity. Transient morbidity included memory deficit (2), aseptic meningitis (1), and local wound infection (1). CONCLUSION:: Endoscopic colloid cyst resection results in a low overall recurrence rate. Immediate postoperative MRI was insufficient for assessing degree of resection, and was a poor predictor of recurrence. Ablation of cyst remnants rather than total removal is associated with a significantly higher rate of recurrence. The primary goal of endoscopic surgery should, therefore, be to remove all cyst contents and wall remnants.
    Neurosurgery 04/2013; · 3.03 Impact Factor
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    ABSTRACT: Introduction. Though traditional microsurgical techniques are the gold standard for intraventricular tumor resection, the morbidity and invasiveness of microsurgical approaches to the ventricular system have galvanized interest in neuroendoscopic resection. We present a systematic review of the literature to provide a better understanding of the virtues and limitations of endoscopic tumor resection. Materials and Methods. 40 articles describing 668 endoscopic tumor resections were selected from the Pubmed database and reviewed. Results. Complete or near-complete resection was achieved in 75.0% of the patients. 9.9% of resected tumors recurred during the follow-up period, and procedure-related complications occurred in 20.8% of the procedures. Tumor size ≤ 2cm (P = 0.00146), the presence of a cystic tumor component (P < 0.0001), and the use of navigation or stereotactic tools during the procedure (P = 0.0003) were each independently associated with a greater likelihood of complete or near-complete tumor resection. Additionally, the complication rate was significantly higher for noncystic masses than for cystic ones (P < 0.0001). Discussion. Neuroendoscopic outcomes for intraventricular tumor resection are significantly better when performed on small, cystic tumors and when neural navigation or stereotaxy is used. Conclusion. Neuroendoscopic resection appears to be a safe and reliable treatment option for patients with intraventricular tumors of a particular morphology.
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