Pharmacokinetics of Nelfinavir and Efavirenz in Antiretroviral-Naive, Human Immunodeficiency Virus-Infected Subjects when Administered Alone or in Combination with Nucleoside Analog Reverse Transcriptase Inhibitors

Adult ACTG Pharmacology Support Laboratory, Laboratory for Antiviral Research, Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 12460, USA.
Antimicrobial Agents and Chemotherapy (Impact Factor: 4.48). 09/2005; 49(8):3558-61. DOI: 10.1128/AAC.49.8.3558-3561.2005
Source: PubMed


Pharmacokinetic studies were conducted with human immunodeficiency virus-infected patients receiving efavirenz, nelfinavir,
or both agents at weeks 4 and 32. Reductions of 25% and 45% were observed in the mean nelfinavir area under the concentration-time
curve and minimum concentration of the drug in serum, and there was a 31% more rapid half-life for patients receiving both
drugs compared to patients receiving nelfinavir alone. There were no significant differences in efavirenz pharmacokinetics.

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Available from: Hulin Wu, Feb 19, 2015
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