Article

Corticospinal tract MRI hyperintensity in X-linked Charcot-Marie-Tooth Disease.

Department of Neurology, University of Ulm, Ulm, Germany.
Journal of Clinical Neuroscience (impact factor: 1.25). 07/2005; 12(5):588-9. DOI:10.1016/j.jocn.2004.07.020
Source: PubMed

ABSTRACT In X-linked hereditary demyelinating neuropathies (CMTX), caused by mutations in Connexin 32, mild subclinical CNS involvement is not unusual. We present a young male patient suffering from genetically proven CMTX who presented with permanent bilateral corticospinal tract hyperintensities in cranial MRI -- a finding previously described to be characteristic for amyotrophic lateral sclerosis. MRI seems to be able to visualize corticospinal tract abnormalities, even if subclinical, in CMTX.

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Keywords

amyotrophic lateral sclerosis
 
CMTX
 
Connexin 32
 
mild subclinical CNS involvement
 
permanent bilateral corticospinal tract hyperintensities
 
visualize corticospinal tract abnormalities
 
X-linked hereditary demyelinating neuropathies
 
young male patient
 

Jan Kassubek