Article

Effect of aqueous extract from Nigella sativa L. on guinea pig isolated heart.

Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, 91735, Iran.
Indian journal of experimental biology (Impact Factor: 0.75). 08/2005; 43(7):635-9.
Source: PubMed

ABSTRACT A potent inhibitory effect of aqueous extract from N. sativa on calcium channel of guinea pig heart was found comparable and even greater than that of diltazem. The results may also indicate an opening effect for the plant on potassium channel of isolated heart.

0 Followers
 · 
86 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Herbal medicines are being centrally focused since ages for the screening of newer and better treatment of health problems especially cardiac diseases. In the current manuscript, we have reviewed a number of important constituents of different herbs and plants, which belong to a wide range of families that affect the cardiovascular system by acting through one mechanism or the other as Rauwolfia serpentine, Nigella sativa, Curcuma longa and Allium sativum. However, there is an evidence for a considerable number of plants such as Phaleria macrocarpa, Inula racemosa, Panax notoginseng etc., that contain constituents affecting the cardiovascular system and can be beneficial for cardiac problems, but still need further investigation and pharmacological evaluation.
    African journal of pharmacy and pharmacology 03/2012; 6(8):563-580. DOI:10.5897/AJPP11.699 · 0.84 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Black Cumin (Nigella sativa), which belongs to the botanical family of Ranunculaceae, commonly grows in Eastern Europe, the Middle East, and Western Asia. Its ripe fruit contains tiny black seeds, known as "Al-Habba Al-Sauda" and "Al-Habba Al-Barakah" in Arabic and black seed or black cumin in English. Seeds of Nigella sativa are frequently used in folk medicine in the Middle East and some Asian countries for the promotion of good health and the treatment of many ailments. However, data for the cardiovascular benefits of black cumin are not well-established. We reviewed the literature from 1960 to March 2012 by using the following key words: "Nigella sativa," "black seeds," and "thymoquinone." Herein, we discussed the most relevant articles to find out the role of Nigella sativa in the cardiovascular diseases spectrum especially when there is a paucity of information and need of further studies in human to establish the utility of Nigella sativa in cardiovascular system protection.
    Cardiovascular toxicology 08/2012; DOI:10.1007/s12012-012-9181-z · 2.06 Impact Factor
  • Edible Medicinal And Non-Medicinal Plants, 01/2013: pages 506-567; , ISBN: 978-94-007-5652-6