Renalase, a catecholamine-metabolizing hormone from the kidney.

Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum-Berlin, Max Delbruck Center for Molecular Medicine, Berlin, Germany.
Cell Metabolism (Impact Factor: 14.62). 07/2005; 1(6):358-60. DOI: 10.1016/j.cmet.2005.05.008
Source: PubMed

ABSTRACT A novel flavin adenine dinucleotide-dependent amine oxidase that is secreted by the kidney, circulates in the blood, and modulates cardiac function and systemic blood pressure has recently been discovered. Renalase appears to be a hormone that metabolizes catecholamines, and its discovery will facilitate our understanding of sympathetic regulation.

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    ABSTRACT: Background and objectives: Renalase, a monoamine oxidase derived from the kidney, can degrade catecholamine (CA) and regulate blood pressure as well as cardiac function. To investigate the changes of serum renalase levels in patients with Type 2 diabetes mellitus (DM) and examine the correlation with other features of T2DM. Methods: Seventy-five patients with T2DM and 13 healthy volunteers were studied. The levels of serum renalase and CA were measured by enzyme linked immunosorbent assay. Several other biochemical and clinical parameters were measured. Results: Serum levels of CA and renalase as well as renalase/CA (R/C) ratio in the T2DM group were significantly higher than those of the control group (p 0.05). There was a highly positive correlation between the levels of serum renalase and CA (r = 0.795, p 0.001). The levels of serum renalase were positively correlated with systolic blood pressure (r = 0.217, p = 0.042) and serum creatinine (SCr) (r = 0.295, p = 0.007), and negatively correlated with eGFR (r = −0.222, p = 0.044). The R/C ratio was positively correlated with SCr (r = 0.347, p = 0.001) as well as homeostasis model assessment for insulin resistance (IR) HOMA2-% S (r = 0.340, p = 0.037). Conclusion: Serum levels of renalase and CA were highly correlated in patients with T2DM. The levels of serum renalase and R/C ratio of T2DM patients were significantly higher than those of healthy subjects and appeared correlated with changes in blood pressure, glomerular filtration rate and IR.
    Renal Failure 01/2014; 36(4). · 0.94 Impact Factor
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    ABSTRACT: Renalase is a kidney-origin monoamine oxidase which can degrade catecholamines and regulate blood pressure and cardiovascular function. Although it has been shown that serum renalase level significantly decreases with impaired renal function, it is not clear whether its level is related to different stages of chronic kidney disease (CKD) in patients. Eighty-seven patients with CKD were selected as subjects of this study to investigate the serum renalase and catecholamine (CA) levels by ELISA method, and their relationship with other renal function indicators. Serum levels of renalase and renalase-catecholamine (R/C) ratios were significantly higher in CKD stage 3-5 patients (217.4 ± 103.8 ng/L, 1.00 ± 0.21) than CKD stage 1-2 patients (162.1 ± 40.1 ng/L, 0.82 ± 0.16; P < 0.05), while there was no significant difference between CKD stage 1-2 patients and the normal control group (167.8 ± 69.4 ng/L, 0.88 ± 0.17; P > 0.05). Renalase levels were linearly correlated with catecholamine levels (R (2) = 0.817; P < 0.01). Serum renalase levels were positively correlated with systolic blood pressure (SBP), serum CA, BUN, SCr, UA, and CKD stage (P < 0.05), while negatively correlated with RBC, Hb and estimated GFR (eGFR) (P < 0.05). R/C ratio was positively correlated with SBP, diastolic blood pressure, BUN, SCr, UA, cystatin C, β2 microglobulin, retinol binding protein-4 and CKD stage (P < 0.05), while negatively correlated with RBC, Hb, eGFR and GFR (P < 0.05). Serum levels of renalase are highly correlated with CA and both serum renalase levels and R/C ratios are related to renal function.
    Clinical and Experimental Nephrology 03/2014; · 1.25 Impact Factor


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