Breast cancer metastasis: Markers and models

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Nature reviews. Cancer (Impact Factor: 37.91). 09/2005; 5(8):591-602. DOI: 10.1038/nrc1670
Source: PubMed

ABSTRACT Breast cancer starts as a local disease, but it can metastasize to the lymph nodes and distant organs. At primary diagnosis, prognostic markers are used to assess whether the transition to systemic disease is likely to have occurred. The prevailing model of metastasis reflects this view--it suggests that metastatic capacity is a late, acquired event in tumorigenesis. Others have proposed the idea that breast cancer is intrinsically a systemic disease. New molecular technologies, such as DNA microarrays, support the idea that metastatic capacity might be an inherent feature of breast tumours. These data have important implications for prognosis prediction and our understanding of metastasis.

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Available from: Laura J van 't Veer, Aug 11, 2015
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    • "A word of caution should be spent about the fact that the event considered in the INT case series was the occurrence of distant metastases, whereas only disease-specific death was available in the METABRIC data set. It is well known that the main cause of death for breast cancer is the development of metastasis at distant sites, rather than the primary tumor (Weigelt et al, 2005), which justifies our analyses in the second cohort. However, it should be noted that also patients untreated after surgery were likely to have received several treatments after relapse and before dying, and no information is available on this aspect. "
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    • "The main cause of death in these patients was its metastases at distant sites. Owing to difficulty in predicting metathesis development many women are over-treated and suffer toxic side effects of chemotherapy (Weigelt et al., 2005). Recent epidemiological studies suggested the presence of an inverse association between regular intake of NSAIDs and the relative risk of breast cancer (Harris et al., 2005; Harris et al., 1995; Harris et al., 1996). "
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    • "Metastasis is the main cause of death in women with breast cancer (1, 2). Breast cancer preferentially metastasizes to specific target organs such as liver, lung, bone marrow and lymph nodes. "
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