Social defeat: risk factor for schizophrenia?

Utrecht University, Utrecht, Utrecht, Netherlands
The British Journal of Psychiatry (Impact Factor: 7.34). 09/2005; 187:101-2. DOI: 10.1192/bjp.187.2.101
Source: PubMed

ABSTRACT The hypothesis that chronic and long-term experience of 'social defeat' may increase the risk for schizophrenia is proposed. This increased risk may result from sensitisation of the mesolimbic dopamine system and/or increased baseline activity of this system. Data supporting the social defeat hypothesis are presented.

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