The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men

Division of Endocrinology and Metabolism, Department of Internal Medicine, Sacred Heart Hospital, Hallym University, Pyungchon-dong, Dongan-gu, Anyang-city, Kyungki-do, Chunchon, Korea.
Clinical Endocrinology (Impact Factor: 3.46). 09/2005; 63(2):131-8. DOI: 10.1111/j.1365-2265.2005.02312.x
Source: PubMed


Body weight is a significant predictor of bone mass. Hormonal factors such as sex hormones, insulin, leptin and adiponectin are thought to play a role in the mechanisms controlling the association of body weight and fat mass with bone mass. However, contradictory results have been reported for the association between serum adipocytokines and bone mineral density (BMD). We therefore examined whether the serum adipocytokine and ghrelin levels, markers of fat metabolism, are associated with BMD in male adults.
For 80 male adults (average age 54.5 +/- 6.4 years; average body mass index (BMI) 24.4 +/- 2.5 kg/m2), the correlations between serum resistin, leptin, adiponectin and ghrelin levels with BMD were investigated.
Among the adipocytokines, serum resistin levels were negatively correlated with lumbar spine BMD (r = -0.237, P = 0.05). After adjustment was made for age and BMI, log-transformed serum leptin showed a significant negative correlation with lumbar spine BMD, which was not seen on bivariate analysis (r = -0.237, P = 0.039). Femoral neck BMD was marginally associated only with serum adiponectin levels (r = -0.226, P = 0.062). In multiple regression analyses, among the adipokines, only resistin was a significant determinant of lumbar spine BMD, although the variance was small (R2 = 0.256). Serum ghrelin levels were not correlated with the BMD of either body site.
Serum resistin level showed a significant negative correlation with lumbar spine BMD, although the variance was small. Further studies are needed to elucidate the role of adipocytokines in bone metabolism.

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    • "Generally , it seems that adiponectin is not a determinant for BMD. Although adiponectin increases osteoblast differentiation through increasing cyclooxygenase-2 expression in fat tissue [57], various investigations, including our study, show no significant association between adiponectin and BMD [53] [58]. Leptin that is released by adipose tissue is strongly correlated with fat mass [59]. "
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    ABSTRACT: Previously the associations between leptin and adiponectin level with bone mineral density (BMD) have been reported in different populations and occasionally controversial results have been demonstrated. Until now, these relationships in spinal cord injured individuals have not yet been described.
    The spine journal: official journal of the North American Spine Society 06/2014; 15(1). DOI:10.1016/j.spinee.2014.06.009 · 2.43 Impact Factor
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    • "There was no significant association between ghrelin and BMD in a study consisting of 80 male adults. In this study, the effect of alcohol, smoking, and physical activity was not controlled [13]. Also, in a study with 977 old adults, no significant association was found between ghrelin and BMD in either sex after controlling for age and BMI [15]. "
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    ABSTRACT: Ghrelin and peptide YY (PYY) are appetite regulating hormones secreted from the gastrointestinal tract (gut). Aside from their known effect on energy homeostasis, accumulating data indicates that these gut hormones also affect bone metabolism. However, data regarding the influence of ghrelin and PYY on bone density in humans is very limited, and the results are inconclusive. Therefore, this study was designed to investigate the potential association between circulating ghrelin and PYY with bone density indices in the general population. A total of 2257 adult subjects from the CODING (Complex Diseases in the Newfoundland Population: Environment and Genetics) study participated in this investigation. Acylated ghrelin and total PYY were measured in serum after a 12-hour fasting, with the Enzyme- Linked Immunosorbent Assay (ELISA) method. Bone mineral density was measured by dual-energy X-ray absorptiometry at the spine, femoral neck, and total hip. Multiple regression analyses adjusting for age, BMI, physical activity, smoking, and alcohol consumption were employed to analyze the association between serum ghrelin and PYY with bone mineral density parameters. Significant positive associations of ghrelin concentration with L2-L4 BMD, L2-L4 Z-score, femoral neck BMD, femoral neck Z-score, total hip BMD, and total hip Z-score were found in women. No significant correlations between ghrelin and bone density indices were present in men. After dividing the female group into pre-menopausal and post-menopausal, ghrelin was positively correlated with femoral neck Z-score, and total hip Z-score in pre-menopausal women and L2-L4 BMD, and Z-score in post-menopausal group. Moreover, no significant association was discovered between serum PYY and bone density at any site. Our results suggest a beneficial association of circulating ghrelin concentration with bone density in women at the population level. This association is independent of major confounding factors including BMI, physical activity, age, alcohol consumption, and smoking. Effect of menopause on this association seemed to be site specific. However, PYY does not seem to be associated with bone density parameters.
    BMC Endocrine Disorders 09/2013; 13(1):35. DOI:10.1186/1472-6823-13-35 · 1.71 Impact Factor
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    • "Also they found that serum adiponectin levels were not significantly different between the patients with osteoporotic fractures and nonosteoporotic fractures [13–16]. However, most of the researches showed a negative correlation between adiponectin and BMD [17–23]. In a META analysis including 59 studies, a great inverse correlation between adiponectin levels and BMD independent of gender and menopausal status was found. "
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    ABSTRACT: Osteoporosis is a serious social issue nowadays. Both the high morbidity and its common complication osteoporotic fracture load a heavy burden on the whole society. The adipose tissue is the biggest endocrinology organ that has a different function on the bone. The adipocytes are differentiated from the same cell lineage with osteoblast, and they can secrete multiple adipokines with various functions on bone remolding. Recently, several novel adipokines have been identified and investigated thoroughly. In this paper, we would like to highlight the complicated relation between the bone metabolism and the novel adipokines, and it may provide us with a new target for prediction and treatment of osteoporosis.
    International Journal of Endocrinology 02/2013; 2013(2):895045. DOI:10.1155/2013/895045 · 1.95 Impact Factor
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