Osseous metastasis of pineoblastoma: a case report and review of the literature
ABSTRACT To review the literature on the occurrence of osseous metastases in recurrent pineoblastoma, and to report upon the feasibility and efficacy of treatment using intensive conventional chemotherapy to achieve a remission, followed by consolidation with marrow ablative chemotherapy and autologous hemopoietic stem cell rescue.
An adult with isolated extraneural, osseous and bone marrow metastases from a pineoblastoma, received conventional cyclical chemotherapy, followed by consolidation with marrow ablative chemotherapy (thiotepa, carboplatin and temozolomide) and autologous hemopoietic stem cell rescue.
A complete radiographic and histopathologic response was achieved after almost one year of conventional chemotherapy that was tolerated without significant sequelae. Following successful harvesting of peripheral blood stem cells, the patient underwent myeloablative chemotherapy with autologous stem cell rescue, without difficulty in hemopoietic reconstitution and without serious or permanent side effects.
Osseous metastases from pineoblastoma are an extremely rare occurrence. We conclude that conventional chemotherapy can achieve a complete response, and subsequent consolidation with marrow ablative chemotherapy and autologous hemopoietic stem cell rescue is feasible and well tolerated.
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ABSTRACT: Practically, the idea of P-V and Q-V curve is used to determine the maximal reactive margin at load buses to avoid voltage instability. Sometimes the voltage stability study may be limited to identify the violation of the bus voltage constraints. In this paper the p-q curve for the critical bus voltage magnitude is created. Using this p-q curve the probability of the critical voltage violation is estimated for uniformly distributed active and reactive power at a given load bus. The p-q curve is created on the basis of bus impedance, which can be measured or calculated. To illustrate the usefulness of p-q idea the simple numerical example is presented.Power Systems Conference and Exposition, 2004. IEEE PES; 11/2004
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Article: Management of pineal region tumors[Show abstract] [Hide abstract]
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