Solitary fibrous tumor of the oral mucosa--morphological and immunohistochemical profile in the differential diagnosis with hemangiopericytoma.
ABSTRACT The objective was to investigate two cases of solitary fibrous tumor (SFT) of oral mucosa, emphasizing the differential diagnosis with one case of oral hemangiopericytoma (HPC), in terms of their morphological and immunohistochemical features. Solitary fibrous tumors showed cellularity and collagenization varying from area to area, focal perivascular hyalinization, scattered giant nuclei cells and abundant mast cells throughout the tumor. The hemangiopericytoma case exhibited thin-walled and dilated vessels lined with flat endothelial cells, identified by "staghorn appearance". Tumoral cells of solitary fibrous tumor exhibited immunohistochemical positivity for CD34, as well as endothelial cells. The hemangiopericytoma was positive only in endothelial cells. In solitary fibrous tumor, alpha-smooth muscle actin, h-caldesmon and laminin stained the wall vessels. In hemangiopericytoma, on the other hand, the wall vessels were positive only for laminin, which staining was also observed in perivascular tumoral cells. The morphological and immunohistochemical differences observed allowed us to infer these lesions constitute distinct entities.
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Article: Myopericytoma of the oral cavity[Show abstract] [Hide abstract]
ABSTRACT: Background.Myopericytoma is a rare mesenchymal neoplasm of pericytic cells demonstrating myoid differentiation. The lesion typically arises within the subcutaneous tissue of the extremities. We report a case that, to the best of our knowledge, is the first case of myopericytoma involving the soft tissue of the oral cavity.Methods.A 36-year-old woman had a 5-mm sessile, whitish-pink, firm tongue nodule. The patient underwent excisional biopsy, and histopathologic examination as well as immunohistochemical analysis were performed.Results.The differential diagnosis by histologic analysis included solitary fibrous tumor, myofibroma, glomus tumor, and myopericytoma. The results of immunohistochemical analysis, when combined with the histologic features, led to a diagnosis of myopericytoma.Conclusions.Applying strict morphologic criteria and appropriately selective immunohistochemical markers will help to distinguish myopericytoma in the oral cavity. © 2007 Wiley Periodicals, Inc. Head Neck, 2007Head & Neck 05/2007; 29(6):605 - 608. · 2.83 Impact Factor
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ABSTRACT: A case of solitary fibrous tumor of the lip is described. A 65-year-old Japanese woman had a painless mass in her lower lip that gradually increased in size and finally ulcerated. Computed tomography revealed a well-demarcated submucosal mass. On the cut surface, the tumor was well-circumscribed, solid, and yellowish-white with small cystic spaces. Histopathologically, it was encapsulated and consisted of an interlacing proliferation of spindle-shaped cells immunopositive for CD34, vimentin, Bcl-2, and CD99, with scattered salivary glandular structures with irregular cellular arrangements. This is the first case report of solitary fibrous tumor of the lip with reactive hyperplasia of minor salivary gland components based on our review of the literature.Oral Oncology Extra 11/2004; 40(10):107-112.
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ABSTRACT: Solitary fibrous tumor (SFT) is a neoplasm that arises most commonly in pleura. Although SFT occasionally occurs in extrapleural locations, the incidence in the oral cavity is rare. SFT is benign in almost cases and surgical excision is the effective treatment. SFT occurred in the left cheek of a 60-year-old man presented with a painless submucosal mass. The tumor was surgically removed. Immunohistochemical study showed that tumoral cells were negative for SMA, S-100, but positive for Bcl-2, CD34. SFT is easily over-diagnosed if strict criteria are not carefully applied, and strict diagnostic criteria are necessary to avoid confusion of SFT with more aggressive lesions.Maxillofacial Plastic and Reconstructive Surgery. 01/2009; 31(3).