Solitary fibrous tumor of the oral mucosa--morphological and immunohistochemical profile in the differential diagnosis with hemangiopericytoma.
ABSTRACT The objective was to investigate two cases of solitary fibrous tumor (SFT) of oral mucosa, emphasizing the differential diagnosis with one case of oral hemangiopericytoma (HPC), in terms of their morphological and immunohistochemical features. Solitary fibrous tumors showed cellularity and collagenization varying from area to area, focal perivascular hyalinization, scattered giant nuclei cells and abundant mast cells throughout the tumor. The hemangiopericytoma case exhibited thin-walled and dilated vessels lined with flat endothelial cells, identified by "staghorn appearance". Tumoral cells of solitary fibrous tumor exhibited immunohistochemical positivity for CD34, as well as endothelial cells. The hemangiopericytoma was positive only in endothelial cells. In solitary fibrous tumor, alpha-smooth muscle actin, h-caldesmon and laminin stained the wall vessels. In hemangiopericytoma, on the other hand, the wall vessels were positive only for laminin, which staining was also observed in perivascular tumoral cells. The morphological and immunohistochemical differences observed allowed us to infer these lesions constitute distinct entities.
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ABSTRACT: This paper reports on the clinicopathological features of four patients with solitary fibrous tumours arising from the extremities and presents a review of the relevant literature. The patients consisted of three women and one man, with a mean age of 47.8 years. Standard pre-operative work-up data were examined, including: history, clinical examination, plain radiography, computed tomography scans of the lesion and chest, magnetic resonance imaging, angiography, technetium-99m bone scan, thallium-201 scintigraphy and routine laboratory tests. Immunohistochemical staining was performed for CD34, Bcl-2 protein, vimentin, S-100 protein, desmin and smooth muscle actin, and pathological material was reviewed for the presence of histologically malignant components. Immunohistochemically, all of the tumours were diffusely positive for CD34. Clinical and radiological findings of solitary fibrous tumours affecting the extremities are reminiscent of those of aggressive or malignant soft tissue tumours. Pathological and immunohistochemical studies are important in making the correct diagnosis.The Journal of international medical research 04/2010; 38(2):694-704. · 0.96 Impact Factor
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ABSTRACT: This chapter addresses frequently asked practical questions about the application of immunohistochemistry to the central nervous system (CNS). The first table, Table 10.1, is a summary table of frequently used antibodies in the CNS. The markers for individual tumor types in the CNS are given in Tables 10.2–10.20. Tables 10.21–10.34 list markers useful in differential diagnosis of CNS tumors. The last four tables, Tables 10.35–10.38, are markers for non-neoplastic lesions in the CNS, listing the markers for neurodegenerative disorders (Table 10.35), virus and parasite infections (Table 10.36), epilepsy (Table 10.37), and histiocytic disorders (Table 10.38). KeywordsCentral nervous system-Tumors-Immunohistochemistry-Antibodies-Neurodegenerative disease06/2011: pages 119-135;
- Oral surgery, oral medicine, oral pathology and oral radiology. 06/2012;