Article

Lipoprotein(a): Implications for clinical practice

Department of Community and Preventive Medicine, University of Rochester Medical Center, Rochester, NY 14627, USA.
Current Atherosclerosis Reports (Impact Factor: 3.06). 10/2005; 7(5):327-9. DOI: 10.1007/s11883-005-0041-1
Source: PubMed
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    ABSTRACT: Lipoprotein(a) [Lp(a)] is a lipoprotein subclass well-known among the lipid community to accelerate atherosclerosis and promote thrombosis through incompletely understood mechanism. We report a case of a young man with a healthy lifestyle and no major coronary or vascular risk factors who presented to the emergency department with an acute coronary syndrome and was ultimately found to have severe coronary artery disease. A diagnostic workup revealed elevated Lp(a). He was treated with consequent reduction in Lp(a) concentration. This case highlights the need to better understand atypical lipoproteins, how they relate to cardiovascular disease, the implications for screening family members, and the need to standardize patient management guidelines for the purpose of mortality risk reduction.
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