A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2581, USA.
The Journal of Infectious Diseases (Impact Factor: 5.78). 10/2005; 192(6):1061-5. DOI: 10.1086/432732
Source: PubMed

ABSTRACT Human metapneumovirus (hMPV) is a recently described paramyxovirus associated with upper and lower respiratory-tract infection (URI and LRI, respectively). We conducted a prospective study of URI and LRI in adults with hematologic malignancies during a 4-year period. We retrospectively tested samples by reverse-transcription polymerase chain reaction for hMPV and analyzed clinical data. Twenty-two (9%) of 251 episodes of respiratory infection tested positive for hMPV. Sixteen (73%) of the illnesses occurred in hematopoietic stem-cell transplant recipients. Nine patients with hMPV developed LRI; 3 of these patients died. hMPV is a common cause of respiratory infections in adults with hematologic malignancies, with associated morbidity and mortality.

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Available from: James E Crowe, Aug 12, 2015
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    • "HMPV is related to respiratory syncytial virus (RSV), which is the most significant respiratory pathogen of infancy and early childhood. Epidemiologic studies showed that HMPV is associated with significant morbidity in infants and other high-risk populations, such as immunocompromised patients [2] [3] [4] [5]. Thus, HMPV is an important cause of hospitalizations, in the same way as the other respiratory viruses, RSV, parainfluenza virus or influenza virus [6]. "
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    ABSTRACT: Human metapneumovirus (HMPV) is a paramyxovirus that causes acute respiratory-tract infections in children and adults worldwide. A safe and effective vaccine could decrease the burden of disease associated with this novel pathogen. We engineered HMPV viral-like particles (HMPV-VLPs) derived from retroviral core particles that mimic the properties of the viral surface of two HMPV viruses of either lineage A or B. These VLPs functionally display F and G HMPV surface glycoproteins. When injected in mice, HMPV-VLPs induce strong humoral immune response against both homologous and heterologous strains. Moreover, the induced neutralizing antibodies prevented mortality upon subsequent infection of the lungs with both homologous and heterologous viruses. Upon challenge, viral titers in the lungs of immunized animals were significantly reduced as compared to those of control animals. In conclusion, a HMPV-VLP vaccine that induces cross-protective immunity in mice is a promising approach to prevent HMPV infections.
    Vaccine 04/2013; 31(25). DOI:10.1016/j.vaccine.2013.03.051 · 3.49 Impact Factor
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    • "hMPV is now widely recognized as an opportunistic infection in immunocompromised hosts such as hematopoietic stem cell transplant (HSCT) and pulmonary transplant recipients, leading to a significant respiratory morbidity [6]. Although its detection is not yet routinely performed, hMPV appears to account for 9% of acute pneumonia in patients with haematologic malignancies (including HSCT), in a similar proportion to RSV [7]. This rate is close to that reported in lung transplant recipients, ranging from 6% to 12% of LRI [6] [8]. "
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    ABSTRACT: Human metapneumovirus (hMPV) is emerging as a cause of a severe respiratory tract infection in immunocompromised patients. hMPV pneumonia has only been seldom reported in nonpulmonary solid organ transplanted patients, such as renal transplant recipients. We report here a case of a 39-year-old patient presenting with fever, cough, and interstitial opacities on CT scan diagnosed as a nonsevere hMPV pneumonia 11 years after a renal transplantation. Infection resolved spontaneously. Differential diagnosis with Pneumocystis pneumonia was discussed. We review the medical literature and discuss clinical presentation and detection methods that can be proposed in solid organ transplant recipients.
    11/2012; 2012:353871. DOI:10.1155/2012/353871
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    • "First identified by van den Hoogen and colleagues in 2001, HMPV is a causative agent of acute respiratory tract infections (van den Hoogen et al., 2001). Primarily at risk of severe HMPV-related disease are infants, immunocompromised patients and the elderly (Boivin et al., 2002; O'Gorman et al., 2006; Sivaprakasam et al., 2007; van den Hoogen et al., 2004b, 2003; Williams et al., 2005). Infection with HMPV can be both symptomatic and asymptomatic (Bruno et al., 2009). "
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    ABSTRACT: First identified in 2001, human metapneumovirus (HMPV) is a novel pathogen and causative agent of acute respiratory tract infection. Re-infection with HMPV is common, and currently there is no available vaccine against HMPV infection. Two genotypes of HMPV have been identified, A and B, both of which can be divided further into at least two distinct sub-genotypes. Here we report the results of the first study to investigate the genetic variability of HMPV strains circulating within Cambodia. The overall incidence of HMPV infection amongst an all-ages population of patients hospitalised with ALRI in Cambodia during 3 consecutive years, between 2007 and 2009, was 1.7%. The incidence of HMPV infection was highest amongst children less than 5 years of age, with pneumonia or bronchopneumonia the most frequent clinical diagnoses across all age groups. The incidence of HMPV infection varied annually. As anticipated, genetic diversity was low amongst the conserved F gene sequences but very high amongst G gene sequences, some strains sharing as little as 56.3% and 34.2% homology at the nucleotide and amino acid levels, respectively. Simultaneous co-circulation of strains belonging to the HMPV sub-genotypes B1, B2 and lineage A2b, amongst patients recruited at 2 geographically distinct provincial hospitals, was detected. Sub-genotype B2 strains were responsible for the majority of the infections detected, and a significant (p=0.013) association between infection with lineage A2b strains and disease severity was observed.
    Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases 02/2011; 15. DOI:10.1016/j.meegid.2011.01.016 · 3.26 Impact Factor
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