Article

Inhibition of RNA polymerase by streptolydigin: no cycling allowed.

Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
Cell (impact factor: 32.4). 09/2005; 122(4):494-6. DOI:10.1016/j.cell.2005.08.008 pp.494-6
Source: PubMed

ABSTRACT Bacterial RNA polymerase is a common target for many antibiotics. In two recent papers in Cell and Molecular Cell, and describe a structural basis for inhibition of bacterial RNA polymerase by the antibiotic streptolydigin. Streptolydigin may prevent distortion of a "bridge" alpha helix postulated to occur during the nucleotide addition cycle of RNA polymerase or may block a small movement of the bridge helix that helps load nucleotide triphosphates into the active site.

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Keywords

active site
 
alpha helix postulated
 
antibiotic streptolydigin
 
Bacterial RNA polymerase
 
bridge helix
 
common target
 
helps load nucleotide triphosphates
 
nucleotide addition cycle
 
recent papers
 
RNA polymerase
 
Streptolydigin
 
structural basis
 

Scotty Kyzer