Decidualization of ovarian endometriosis during pregnancy mimicking malignancy.
ABSTRACT The purpose of this series is to present deciduosis (the formation of extrauterine decidua) as one of the differential diagnoses of a malignant tumor during pregnancy.
Two cases are described in which pregnant patients had a pelvic tumor. The lesions, which were diagnosed in the early second trimester, consisted of complex masses with an extensive blood supply and had a sonographic appearance of a malignant tumor. The high suspicion for malignancy necessitated surgical intervention.
During surgery, the lesions were observed to be of an ovarian origin with papillary excrescences covering their exterior. The lesions were excised and sent for histologic examination. The results showed a markedly decidualized endometriotic cyst in both cases.
This phenomenon is a diagnostic challenge and should be considered in the differential diagnosis of a malignant mass during pregnancy.
- SourceAvailable from: Dileta Rutkauskaite[Show abstract] [Hide abstract]
ABSTRACT: The occurrence of ectopic decidua has been observed mostly in the ovaries, uterus and cervix. Ectopic gastrointestinal deciduosis is a physiological condition. Only several cases of ectopic decidua, causing complications have been presented in literature. To the best of our knowledge, sigmoid or any other bowel perforation, caused by deciduosis, has not been previously reported in literature. Case presentation: A 40-year old patient primigravida (32 weeks of gestation) was admitted with a severe abdominal pain and obstipation. An abdominal sonography was performed but no visual cause of the pain was diagnosed. Two days after admission the episode of severe pain reappeared. An abdominal sonography and x-ray showed “free air” under both domes of diaphragm. A laparotomy was performed. No perforation of hollow viscus was found. On the fifth postoperative day, the patient started to complain about acute abdominal pain. The decision was made to perform relaparotomy (a Caesarean section and reexploration of abdominal cavity during the same operation). During the relaparotomy a part of sigmoid colon was visually altered. A microperforation on tumour-like structures was found in the sigmoid colon. A Sigmoid resection was performed. Currently the patient has no residual complaints and is enjoying her motherhood. Conclusion: We assert that ectopic decidua can result in a perforation of the hollow viscus, which is a lifethreatening condition and should always be taken into account seriously. We believe that sigmoid microperforation could have found, we had taken a more aggressive approach and performed a Caesarean section during the first operation.Journal of Clinical Case Reports. 07/2012; 2(11):168.
- [Show abstract] [Hide abstract]
ABSTRACT: Superficial decidualization of the endometrial stroma is an essential feature of the implantation stage of pregnancy in rhesus macaques and other primates. Decidualization involves proliferation of the endometrial stromal cells, with differentiation into morphologically distinct decidual cells. Previous reports involving nonpregnant rhesus monkeys have described local- ized and widespread endometrial decidualization in response to administration of progesterone and synthetic progestogens. Ectopic decidua or 'deciduosis' describes the condition in which groups of decidual cells are located outside of the endometrium, most often in the ovaries, uterus and cervix but also in various other organs. In humans, most cases of deciduosis are associated with normal pregnancy, and ectopic decidua can be found in the ovary in nearly all term pregnancies. Here we describe pronounced endometrial decidualization in 2 rhesus macaques. Both macaques had been treated long-term with medroxyprogesterone acetate for presumed endometriosis, which was confirmed in one of the macaques at postmortem examination. In one animal, florid extrauterine and peritoneal serosal decidualization was admixed multifocally with carcinomatosis from a primary colonic adenocarcinoma. Cells constituting endometrial and serosal decidualization reactions were immunopositive for the stromal markers CD10, collagen IV, smooth muscle actin, and vimentin and immunonegative for cytokeratin. In contrast, carcinomatous foci were cytokeratin-positive. To our knowledge, this report describes the first cases of serosal peritoneal decidualization in rhesus macaques. The concurrent presentation of serosal peritoneal decidualization with carcinomatosis is unique.Comparative medicine 01/2014; 64(2):148-56. · 0.76 Impact Factor
- Ultrasound quarterly. 09/2014; 30(3):211-2.