Neuroendocrine Profiles Associated with Energy Intake, Sleep, and Stress in the Night Eating Syndrome

Department of Psychiatry, Cornell University, Итак, New York, United States
Journal of Clinical Endocrinology &amp Metabolism (Impact Factor: 6.21). 11/2005; 90(11):6214-7. DOI: 10.1210/jc.2005-1018
Source: PubMed


Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings with ingestion of food. It is associated with obesity and depressed mood. Greater understanding of hormonal influences on NES is desirable.
Our objective was to evaluate 25-h profiles of hormones involved in energy balance, sleep, and stress in NES.
Blood assays for glucose, insulin, ghrelin, leptin, melatonin, cortisol, TSH, and prolactin were sampled repeatedly among NES and control subjects. Food intake and depressive symptoms were assessed.
Fifteen NES and 14 matched control participants stayed three nights in a General Clinical Research Center.
We assessed differences between NES and control participants in the 25-h profiles of eight hormones.
Nocturnal food intake was higher among NES participants, although their daily calorie intake was similar to that of controls. Reflecting their increased nocturnal intake, insulin (P < 0.001) and glucose levels (P = 0.07) among NES participants were higher than those of controls. Ghrelin levels were significantly lower in NES participants than in controls from 0100-0900 h (P = 0.003). Levels of plasma cortisol, melatonin, leptin, and prolactin did not differ between groups, but there was a trend for TSH levels (P = 0.07) to be higher during the 25 h in NES. NES participants had greater depressive symptoms than controls (P < 0.001). The differences in the levels of glucose, insulin, and ghrelin between NES and controls are closely associated with nocturnal food intake.

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    • "Additional factors that contribute to the NES and its night binging are leptin [7-9] (the hormone that is believed to suppress appetite and speed up metabolism), certain medications and highly restrictive and prolonged dieting among obese individuals. Even the regulation of ghrelin [9], an endogenous ligand receptor growth hormone (GH), which affects not only food but also control induction of sleep is altered in the NES [9]. "
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    ABSTRACT: The NES is an emerging disease in eating behavior that combines eating disorders, sleep, mood and stress. In recent years, the NES is becoming more interested in close association with obesity and depression. In the present study we have followed for 12 weeks 5 patients (2 males and 3 females) with NES and comorbid depression treated with agomelatine (25 mg / day for the first two weeks, then 50 mg / day), an antidepressant similar of melatonin. At the end of the three months of treatment, it was found an improvement in symptoms characteristic of the NES, as assessed by a reduction an average of the NEQ (from 31 to 22.8), improved mood, mean values reduced by 23, 2 to 13.2 on the HAM-D, weight reduction, an average of 3.6 kg reduction in average weekly awakenings from 12 to 6.4 and the time of snoring and motion detected polysomnography. The serum chemistry values remained stable and there were no reported adverse events. The present study showed that the treatment with agomelatine has improved the symptoms of NES and mood, decrease of body weight, reduce, albeit not in an optimal manner, the number of awakenings per night with a reduction of movement time and snoring . Of course, these preliminary data need to be confirmed by controlled trials on a larger sample.
    The Open Neurology Journal 07/2013; 7(1):32-7. DOI:10.2174/1874205X20130626001
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    • "Additional factors that contribute to the NES and its nocturnal ingestion are leptin [7–9] (the hormone that is believed to suppress appetite and speed up metabolism), certain medications, and highly restrictive and prolonged dieting among obese individuals. Even the regulation of ghrelin [9], an endogenous ligand receptor growth hormone (GH), which affects not only food but also control induction of sleep, is altered in the NES [9]. "
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    ABSTRACT: Night eating syndrome (NES) is a nosographic entity included among the forms not otherwise specified (EDNOS) in eating disorders (ED) of the DSM IV. It is characterized by a reduced food intake during the day, evening hyperphagia, and nocturnal awakenings associated with conscious episodes of compulsive ingestion of food. Frequently, NES patients show significant psychopathology comorbidity with affective disorders. This paper describes a case report of an NES patient treated with agomelatine, an antidepressant analogue of melatonin, which acts by improving not only the mood but also by regulating sleep cycles and appetite. After three months of observation, the use of Agomelatine not only improved the mood of our NES patient (assessed in the HAM-D scores) but it was also able to reduce the night eating questionnaire, by both reducing the number of nocturnal awakenings with food intake, the time of snoring, the minutes of movement during night sleep (assessed at polysomnography), and the weight (-5.5 kg) and optimizing blood glucose and lipid profile. In our clinical case report, agomelatine was able both to reduce the NES symptoms and to significantly improve the mood of our NES patient without adverse side effects during the duration of treatment. Therefore, our case report supports the rationale for further studies on the use of Agomelatine in the NES treatment.
    Case Reports in Medicine 05/2013; 2013:867650. DOI:10.1155/2013/867650
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    • "The metabolic and dietary associations with NES are not well established, and recent evidence has refuted an association with metabolic syndrome and body mass index (BMI) [6]. No association between NES and total daily calories consumed has been found to date [7]. "
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    ABSTRACT: The prevalence of Night Eating Syndrome (NES) in the general population is estimated to be 1.5%, however, the rates among individuals with schizophrenia and schizoaffective disorder are not yet established. This study sought to examine the frequency and correlates of NES-related behaviors in a sample of obese patients with schizophrenia. One-hundred outpatients diagnosed with schizophrenia or schizoaffective disorders completed the self-report Night Eating Questionnaire (NEQ) and were then interviewed as a follow-up for the specific assessment of NES. Based on a diagnostic interview, 12% of this sample met full criteria for NES, with an additional 10% meeting partial criteria for NES. Based on the NEQ alone, 8% met full criteria with an additional 8% meeting partial criteria. Night eating behaviors were associated with increased insomnia and depression. Our findings suggest that screening for NES among patients with serious mental illness may efficiently identify a subgroup with additional clinical needs.
    Comprehensive psychiatry 09/2012; 54(3). DOI:10.1016/j.comppsych.2012.07.014 · 2.25 Impact Factor
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