Gabapentin-induced severe myoclonus in a patient with impaired renal function

Journal of Neurology (Impact Factor: 3.84). 04/2006; 253(3):382-3. DOI: 10.1007/s00415-005-0970-1
Source: PubMed

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    • "As with gabapentin, dialysis has been utilized to treat pregabalin neurotoxicity and myoclonic activity [20] [21]. Fifth, a threshold effect for the development of myoclonic activity with gabapentin and pregabalin has been previously reported [19] [22]. This is consistent with the concept that adverse events for specific AEDs may require an individual threshold concentration which may be within the reference range [14] [23] [24]. "
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    ABSTRACT: Gabapentin, an AED approved for the adjunctive treatment of partial seizures with/without secondary generalization and for the treatment of postherpetic neuralgia, is frequently used off-label for the treatment of both psychiatric and pain disorders. Since gabapentin is cleared solely by renal excretion, dosing requires consideration of the patient's renal function. Myoclonic activity may occur as a complication of gabapentin toxicity, especially with acute kidney injury or end-stage renal disease. We report 2 cases of myoclonic activity associated with gabapentin toxicity in the setting of renal disease which resolved with discontinuation of gabapentin and treatment with hemodialysis and peritoneal dialysis. As gabapentin has multiple indications and off-label uses, an understanding of myoclonus, neurotoxicity, and renal dosing is important to clinicians in multiple specialties.
    01/2014; 2:8–10. DOI:10.1016/j.ebcr.2013.12.002
  • Article: Myoclonus.
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