Sustained Remission of Schizophrenia

American Journal of Psychiatry (Impact Factor: 12.3). 10/2005; 162(9):1763; author reply 1763-4. DOI: 10.1176/appi.ajp.162.9.1763
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    ABSTRACT: A definition of clinical remission in schizophrenia has recently been proposed. However, it is also known that neuropsychological (NP) impairments may be better predictors of functional outcomes than clinical symptoms. Understanding the relationship between clinical remission and cognitive improvement may be required in order to predict functional improvements, so we examined the development and convergence of clinical remission and neuropsychological improvements in a sample of patients with schizophrenia whose medication was switched to ziprasidone.
    Schizophrenia Research 09/2007; 94(1-3):99-106. DOI:10.1016/j.schres.2006.12.032 · 3.92 Impact Factor
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    ABSTRACT: Schizophrenia is a serious and prolonged illness between whose psychosocial treatments one of the most effective is the psychoeducation. This treatment involves the family and succeeds in reducing rates of relapse and improves the course of the illness. The Psychiatry Service of Zamora years ago develops an intervention of this kind. In Zamora, the geographical and transport are obstacles who characterize its territory, and cause of some difficulties in access of families to this important therapy. In view of this circumstances an alternative is develop a distance therapy founded in internet. This work is an approach to test this possibility. This research conducted an exhaustive review of the literature regarding psychoeducation as e-therapy. Analyzed the results of the traditional treatment previously made by the Service of Zamora, and explored the difficulties of access for their users. The results indicate that the intervention traditional in Zamora increases knowledge and requires some improvement; also described the difficulties that families have accessing to the intervention (mainly distance and transportation). Finally, both families and professionals would be prepared to use a therapy at a distance based on Internet. This research has developed a methodology for analysis of the instruments used in the Service of Zamora; has known the outcome of the psychoeducational intervention; have been identified the difficulties in access to interventions and; have been explored the possible acceptances of an e-therapy. These results are the foundation and justification to develop a psychoeducational program called PsicoED that fits the pattern of service to the needs of its population.
    01/2008, Degree: Salamanca, Supervisor: Franco, M.; Jiménez, F.
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    ABSTRACT: The concepts of partial recovery and remission have become increasingly important for the evaluation of the effectiveness of schizophrenia therapeutics. The relationship of baseline symptoms and changes in symptoms to remission of psychosis was evaluated. Fifty-six outpatients with residual schizophrenia completed a double-blind trial of olanzapine versus haloperidol and were then enrolled into a one-year open-label trial of olanzapine. Out of these 56 subjects, 13 (23%) met remission criteria at the beginning of the open-label treatment and were excluded. During the one-year study, 7/43 (16%) subjects met remission criteria. These subjects had significantly lower baseline ratings for tardive dyskinesia (TD) than subjects who did not achieve remission (1.8 +/- 1.5 vs. 4.2 +/- 4.6, P = 0.03). As expected, remitted subjects had significantly greater improvements in Brief Psychiatric Rating Scale total scores, positive subscale scores and scale for the Assessment of Negative Symptoms total scores. Remitted subjects also experienced a significantly greater improvement in depressive symptoms (P = 0.001), activation (P = 0.005), and Clinical Global Impressions scores (P < 0.001), as well as greater improvements in extrapyramidal symptoms (P = 0.007) and TD (P < 0.001). These results suggest that the relationship of depressive symptoms and improved side effects to the construct of remission in schizophrenia may deserve special attention. Future studies should aim to relate remission criteria to functional outcomes, cognition, and other important symptom domains.
    Journal of Psychopharmacology 06/2008; 23(4):436-41. DOI:10.1177/0269881108093883 · 3.59 Impact Factor
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