Altered Brain Serotonin 5-HT1A Receptor Binding After Recovery From Anorexia Nervosa Measured by Positron Emission Tomography and [Carbonyl11C]WAY-100635

Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA.
Archives of General Psychiatry (Impact Factor: 14.48). 10/2005; 62(9):1032-41. DOI: 10.1001/archpsyc.62.9.1032
Source: PubMed


Previous studies have shown that women with anorexia nervosa (AN), when ill and after recovery, have alterations of serotonin (5-HT) neuronal activity and core eating disorder symptoms, such as anxiety.
To further characterize the 5-HT system in AN, we investigated 5-HT1A receptor activity using positron emission tomography imaging because this receptor is implicated in anxiety and feeding behavior.
To avoid the confounding effects of malnutrition, we studied 13 women who had recovered from restricting-type AN (mean age, 23.3 +/- 5.2 years) and 12 women who had recovered from bulimia-type AN (mean age, 28.6 +/- 7.3 years) (>1 year normal weight, regular menstrual cycles, no bingeing or purging). These subjects were compared with 18 healthy control women (mean age, 25.1 +/- 5.8 years). Intervention The 5-HT1A receptor binding was measured using positron emission tomography imaging and a specific 5-HT1A receptor antagonist, [carbonyl-11C]WAY-100635.
Specific 5-HT1A receptor binding was assessed using the binding potential measure. Binding potential values were derived using both the Logan graphical method and compartmental modeling. The binding potential in a region of interest was calculated with the formula: binding potential = distribution volume of the region of interest minus distribution volume of the cerebellum.
Women recovered from bulimia-type AN had significantly (P<.05) increased [11C]WAY-100635 binding potential in cingulate, lateral and mesial temporal, lateral and medial orbital frontal, parietal, and prefrontal cortical regions and in the dorsal raphe compared with control women. No differences were found for women recovered from restricting-type AN relative to controls. For women recovered from restricting-type AN, the 5-HT1A postsynaptic receptor binding in mesial temporal and subgenual cingulate regions was positively correlated with harm avoidance.
We observed increased 5-HT1A receptor binding in women who had recovered from bulimia-type AN but not restricting-type AN. However, 5-HT1A receptor binding was associated with a measure of anxiety in women recovered from restricting-type AN. These data add to a growing body of evidence showing that altered serotonergic function and anxiety symptoms persist after recovery from AN. These psychobiological alterations may be trait related and may contribute to the pathogenesis of AN.

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    • "Biological marker Age PET effect Brain region Recovered ED (sample size, n's) Serotonin system 5-HT1a receptor Bailer et al., 2005 "
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    Journal of Child Psychology and Psychiatry 06/2015; 56(11). DOI:10.1111/jcpp.12441 · 6.46 Impact Factor
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    • "rers have been reported to have diminished binding potential for 5 - HT 2A and increased binding potential of 5 - HT 1A . Audenaert et al . ( 2003 ) reported significantly reduced 5 - HT 2A binding in the left frontal cortex as well as the left and right parietal and occipital cortices of individuals with AN in comparison to control participants . Bailer et al . ( 2005 ) , on the other hand , reported increased 5 - HT 1A binding potential of the dorsal raphe , and the cingulate , lateral and medial tempo - ral , lateral and medial orbitofrontal , parietal and prefrontal cortices in weight - recovered AN . Studies investigating the specific subtypes of AN found that weight - restored restrict - ing sub"
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    ABSTRACT: Objective: Recent advances in neuroimaging techniques have enabled a better understanding of the neurobiological underpinnings of anorexia nervosa (AN). The aim of this paper was to summarise our current understanding of the neurobiology of AN. Methods: The literature was searched using the electronic databases PubMed and Google Scholar, and by additional hand searches through reference lists and specialist eating disorders journals. Relevant studies were included if they were written in English, only used human participants, had a specific AN group, used clinical populations of AN, group comparisons were reported for AN compared to healthy controls and not merely AN compared to other eating disorders or other psychiatric groups, and were not case studies. Results: The systematic review summarises a number of structural and functional brain differences which are reported in individuals with AN, including differences in neurotransmitter function, regional cerebral blood flow, glucose metabolism, volumetrics and the blood oxygen level dependent response. Conclusion: Several structural and functional differences have been reported in AN, some of which reverse and others which persist following weight restoration. These findings have important implications for our understanding of the neurobiological underpinnings of AN, and further research in this field may provide new direction for the development of more effective treatments.
    Australian and New Zealand Journal of Psychiatry 01/2014; 48(2):128-152. DOI:10.1177/0004867413509693 · 3.41 Impact Factor
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    • "renourishment in AN, and thus could represent an index of disease status, include abnormalities of the dopamine (Kaye et al., 1999; Bergen et al., 2005) and serotonin (Bailer et al., 2005; Galusca et al., 2008) neurotransmitter systems. The majority of such studies, however, tested a single candidate biomarker that is a part of a metabolic or neurochemical system believed to be related to the etiology of AN. "
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    06/2013; 210(1). DOI:10.1016/j.psychres.2013.05.026
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