A novel interstitial deletion on the long arm of chromosome 16 in a patient with chronic myelomonocytic leukemia
Human Genetics Program, Hayward Genetics Center and Department of Pediatrics, Tulane University Health Science Center, 1430 Tulane Avenue, New Orleans, LA 70112Cancer Genetics and Cytogenetics (Impact Factor: 1.93). 11/2005; 162(1):92-4. DOI: 10.1016/j.cancergencyto.2005.02.004
Chapter: Modern Clinical Molecular Techniques[Show abstract] [Hide abstract]
ABSTRACT: Genetic alterations are important biological markers for cancer diagnosis and prognosis, disease classification, risk stratification, and treatment selection. Microarray-based cytogenetic technology is a superb new method for evaluating cancer genomes. This technology offers high-resolution, highly accurate targeted and whole genome evaluation of tumor tissues independent of cell division. Application of microarray-based technology in cancer research has generated a wealth of useful information about copy number variations (CNVs) and their implications in cancer classification, disease progression, therapy response, and patient outcome. There is an increasing interest in the genetic diagnostic community in applying this new technology to cancer diagnosis in CLIA certified laboratories. We anticipate that microarray-based cancer cytogenetics will soon become one of the major diagnostic means for cancer genome analysis, especially for solid tumors and hematological malignancies with prominent genomic imbalances.Modern Clinical Molecular Techniques, 01/2012: pages 307-322; , ISBN: 978-1-4614-2169-6
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