Article

The macrophage scavenger receptor CD163

Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdamo, North Holland, Netherlands
Immunobiology (Impact Factor: 3.18). 02/2005; 210(2-4):153-60. DOI: 10.1016/j.imbio.2005.05.010
Source: PubMed

ABSTRACT Mature tissue macrophages form a first line of defense to recognize and eliminate potential pathogens; these specialized cells are capable of phagocytosis, degradation of self and foreign materials, establishment of cell-cell interactions, and the production of inflammatory mediators. Mature tissue macrophages express a variety of receptors, including the scavenger receptor cystein-rich (SRCR) superfamily members. CD163 is a member of the SRCR family class B and is expressed on most subpopulations of mature tissue macrophages. The best characterized function of CD163, which is essentially a homeostatic one, is related to the binding of Hemoglobin:Haptoglobin complexes. Furthermore, it has been suggested that CD163 positive macrophages or the soluble form of CD163 plays a role in the resolution of inflammation, as they are found in high numbers in inflamed tissue.

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