Preterm premature rupture of the fetal membranes: Current concepts
Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA. Minerva ginecologica
Preterm birth and preterm premature rupture of membranes (PPROM) are common causes of perinatal morbidity and mortality. Fetal membrane integrity is regulated partially by collagenases and inhibitors. A number of genetic polymorphisms with genes related to infection, inflammation and collagen degradation have been identified and studies as risk factors for PPROM. This manuscript reviews the state of the science on the pathophysiology of PPROM and possible genetic influences.
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