Article

Congenital vitamin K-dependent coagulation factor deficiency: a case report.

Department of Haematology, All India Institute of Medical Sciences, New Delhi, India.
Blood Coagulation and Fibrinolysis (Impact Factor: 1.38). 11/2005; 16(7):525-7. DOI: 10.1097/01.mbc.0000183634.68071.3b
Source: PubMed

ABSTRACT Congenital vitamin K-dependent coagulation factor deficiency is a very rare bleeding disorder, which usually presents with episodes of intracerebral bleed in the first few weeks of life, sometimes leading to a fatal outcome. We report a case of combined factor deficiency of vitamin K-dependent factors in which the patient presented with both intracerebral bleeding, and possibly also thrombosis, and responded to a vitamin K supplement along with fresh frozen plasma.

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    • "Hemarthrosis is rarely described [8]. VKCFD can sometimes cause fatal intracranial haemorrhage in the first weeks of life, which is similar to the haemorrhagic disease the newborns that results form acquired vitamin K deficiency [6,7,16]. The case of a woman with persistent menorrhagia, but whose worst bleeding episodes occurred mainly in a surgical scenario, such as post-partum haemorrhage and haemoperitoneum following ovarian cyst rupture, has been described [17]. "
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