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[Expression of urotensin II and G-protein coupled receptor 14 mRNA in human pheochromocytoma tissues].

Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 08/2005; 27(4):457-60.
Source: PubMed

ABSTRACT To investigate the expression of urotensin II (U II) and G-protein coupled receptor 14 (GPR14) mRNA in human pheochromocytoma tissues.
Total RNA from normal adrenal and pheochromocytoma tissues was extracted. The reverse transcription-polymerase chain reaction method was used to evaluate the levels of U II and GPR14 mRNA expression in human pheochromocytoma tissues.
There was no significant difference of U II and GPR14 mRNA expression between normal adrenal cortex and medulla. The expression of U II and GPR14 mRNA in pheochromocytoma was significantly lower than that in normal adrenal cortex and medulla (P < 0.05). The expression of GPR14 mRNA in adrenal pheochromocytomas was significantly lower than that of extra-adrenal pheochromocytomas (P < 0.05).
U II and GPR14 may play a role in the pathogenesis and hypertension regulating of pheochromocytoma.

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