Intraoral mucin-rich salivary duct carcinoma

Department of Pathology and Laboratory Medicine, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States
Histopathology (Impact Factor: 3.45). 11/2005; 47(4):436-7. DOI: 10.1111/j.1365-2559.2005.02136.x
Source: PubMed
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    ABSTRACT: Salivary duct carcinoma is a rare aggressive malignancy occurring most often in the parotid gland and less commonly in the minor salivary glands. This report describes a patient with salivary duct carcinoma originating from the oral floor. A 60-year-old Japanese woman presented with a painless mass on the left oral floor for 1 month. The tumour was diagnosed as a salivary duct carcinoma. At the 5-year follow-up, the patient remains in good health and free of disease.
    Asian Journal of Oral and Maxillofacial Surgery 03/2008; 20(1):29–33. DOI:10.1016/S0915-6992(08)80006-4
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    ABSTRACT: It has been difficult cytologically to distinguish salivary duct carcinoma (SDC) from high-grade carcinoma. We investigated the microscopic cytological findings, morphometric image analyses, and immunohistochemical features of SDC, focusing on how we achieved an accurate differential diagnosis distinguishing SDC from salivary gland carcinomas with squamous differentiation. Immunohistochemical staining was performed for androgen receptor (AR), gross cystic disease fluid protein-15 (GCDFP15), mammaglobin, human gastric mucin, MUC1, MUC2, p63, and cytokeratin high molecular weight. Of the 13 cases of SDC, 9 cases showed typical cytological findings of sheet clusters with polygonal granular cytoplasm with fine chromatin. The other 4 cases showed unusual cytological findings of a pseudo-papillary cluster or scattered cells only, and the tumor cells showed coarse chromatin. Morphometric image analysis showed that the nucleus area was statistically different between SDC and salivary gland carcinomas with squamous differentiation. AR-positive expression (P = 0.008), GCDFP15-positive expression (P = 0.005) and p63-negative expression (P = 0.001) were effective as SDC-specific markers in immunohistochemistry. An accurate cytological diagnosis of SDC can be determined by immunostaining with AR, GCDFP15, and p63, based on the nuclear findings. Diagn. Cytopathol. 2008;36:485–493. © 2008 Wiley-Liss, Inc.
    Diagnostic Cytopathology 07/2008; 36(7):485 - 493. DOI:10.1002/dc.20823 · 1.12 Impact Factor
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    ABSTRACT: Salivary gland mucinous adenocarcinoma (MAC) is a rarely encountered and poorly understood tumor. We describe two additional cases presenting as a lip lesion of older women. The prognosis was dismal with one death and one patient with recurrent/metastatic disease. Combining these with 19 cases in the literature unveiled that intraoral MAC occurred primarily in the palate (43%) of elderly individuals (average 65 years) with slight male preponderance (59%). Tumor evolved slowly (>2 years) and most (60%) were diagnosed at an advanced stage. Local recurrences were common (33%) and cervical lymph node and distant metastases were frequent (63% and 29%, respectively). About half the patients (47%) died of tumor within 6 years. Both histologically and immunohistochemically, MAC lacked acinar, myoepithelial, and neuroendocrine phenotypes. Cytokeratins 7 and 20 and estrogen and progesterone receptors, in some combination, may assist to distinguish primary versus metastatic mucinous carcinoma. Minor salivary gland MAC belongs to a high-grade category with a significant risk of local recurrence, lymph node metastasis, and fatal outcome.
    Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 12/2008; 454(1):55-60. DOI:10.1007/s00428-008-0699-1 · 2.65 Impact Factor
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