Moria and Witzelsucht from frontotemporal dementia.

Journal of Neuropsychiatry (Impact Factor: 2.77). 02/2005; 17(3):429-30. DOI: 10.1176/appi.neuropsych.17.3.429
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    ABSTRACT: Pseudobulbar affect (PBA) is defined by episodes of involuntary crying and/or laughing as a result of brain injury or other neurological disease. Epidemiology studies show that 5.3%-48.2% of people with traumatic brain injury (TBI) may have symptoms consistent with (or suggestive of) PBA. Yet it is a difficult and often overlooked condition in individuals with TBI, and is easily confused with depression or other mood disorders. As a result, it may be undertreated and persist for longer than it should. This review presents the signs and symptoms of PBA in patients with existing TBI and outlines how to distinguish PBA from other similar conditions. It also compares and contrasts the different diagnostic criteria found in the literature and briefly mentions appropriate treatments. This review follows a composite case with respect to the clinical course and treatment for PBA and presents typical challenges posed to a provider when diagnosing PBA.
    Neuropsychiatric Disease and Treatment 10/2014; 10:1903-10. DOI:10.2147/NDT.S63304 · 2.15 Impact Factor
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    ABSTRACT: The Committee on Research of the American Neuropsychiatric Association conducted a review of the noncognitive neuropsychiatric manifestations of frontotemporal dementia. The Committee on Research searched reviews and several online databases for all pertinent publications. Single case reports without pathology were excluded, except for psychosis, where single cases made up much of the literature. The strongest evidence supports an association of frontotemporal dementia with the following behaviors: apathy-abulia; disinhibition-impulsivity; loss of insight and self-referential behavior; decreased emotion and empathy; violation of social and moral norms; changes in dietary or eating behavior; and repetitive behaviors. Frontotemporal dementia is less frequently associated with anxiety and mood disorders, which may be a prodrome or risk factor, and rarely presents with delusions or hallucinations. The results of this review highlight the distinct neuropsychiatric manifestations of frontotemporal dementia and the need to reconsider the current diagnostic criteria for this disorder.
    Journal of Neuropsychiatry 02/2008; 20(2):130-49. DOI:10.1176/appi.neuropsych.20.2.130 · 2.77 Impact Factor
  • Fortschritte der Neurologie ¬∑ Psychiatrie 05/2009; 77(05):289-294. DOI:10.1055/s-0028-1109403 · 0.76 Impact Factor