Article

Prostate cancer risk among men with diabetes mellitus (Spain)

Centro Español de Investigación Farmacoepidemiológica (CEIFE), Madrid, Spain.
Cancer Causes and Control (Impact Factor: 2.96). 12/2005; 16(9):1055-8. DOI: 10.1007/s10552-005-4705-5
Source: PubMed

ABSTRACT Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK.
Population based case-control study nested in a cohort.
We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59-0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50-0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73-1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas.
Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.

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