Worldwide, lentigo maligna melanoma (LMM) comprises 4%-15% of cutaneous melanoma and occurs less commonly than superficial spreading or nodular subtypes. We assessed the incidence of melanoma subtypes in regional and national Surveillance, Epidemiology, and End Results (SEER) cancer registry data from 1990 to 2000. Because 30%-50% of SEER data were not classified by histogenetic type, we compared the observed SEER trends with an age-matched population of 1024 cases from Stanford University Medical Center (SUMC) (1995-2000). SEER data revealed lentigo maligna (LM) as the most prevalent in situ subtype (79%-83%), and that LMM has been increasing at a higher rate compared with other subtypes and to all invasive melanoma combined for patients aged 45-64 and > or =65 y. The SUMC data demonstrated LM and LMM as the only subtypes increasing in incidence over the study period. In both groups, LM comprised > or =75% of in situ melanoma and LMM > or =27% of invasive melanoma in men 65 y and older. Regional and national SEER data suggest an increasing incidence of LM and LMM, particularly in men > or =age 65. An increased incidence of LM subtypes should direct melanoma screening to heavily sun-exposed sites, where these subtypes predominate.
"The frequency of occurrence of the less common cutaneous malignancies such as cutaneous B-cell and T-cell lymphomas , soft tissue sarcomas (for example, dermatofibrosarcoma protuberans (DFSP)), sebaceous carcinoma, and Merkel cell carcinoma is poorly documented. The studies that mention the incidence rates of these rare skin malignancies are mainly using data from the Surveillance, Epidemiology and End Results (SEER) program, which registers pathology reports of nine areas that cover about 10% of the US population (Swetter et al., 2005; Morton et al., 2006; Criscione and Weinstock, 2007; Rouhani et al., 2008; Bradford et al., 2009). Currently, there are over 16.5 million Dutch citizens, of whom the majority is white. "
[Show abstract][Hide abstract] ABSTRACT: Epidemiology of rare cutaneous malignancies in the general population is poorly documented. This descriptive study aimed to estimate the incidence and trends of all skin malignancies between 1989 and 2005. Data on skin tumors were extracted from the Netherlands Cancer registry (except for basal cell carcinoma (BCC) data-only available from Comprehensive Cancer Centre South) and categorized according to the International Classification of Diseases for Oncology, third edition, codes. Age-standardized incidence rates (European standardized population rate, ESR) per 100,000 person-years were calculated per year and for the period between 2001 and 2005. Estimated annual percentage changes (EAPCs) were estimated by Poisson regression models. A total of 356,620 skin tumors were diagnosed between 1989 and 2005. Excluding BCC, squamous cell carcinoma (SCC), and melanoma, the remaining skin tumors constituted about 2% of all skin malignancies. The incidence of melanoma showed the steepest increase (EAPC, 4.0%), and ESR was close to that observed for SCC (EAPC, 2.3%) between 2001 and 2005 (17.1 versus 19.6). Hematolymphoid tumors (ESR=0.74) were mainly cutaneous T-cell lymphomas (60.8%). No significant increases in incidence were observed for lymphomas, and appendageal, fibromatous, and myomatous carcinomas during 1989-2005. In addition to keratinocytic cancers and melanoma, there is a wide variety of skin tumors that constitute <2% of all skin malignancies. The incidence of UV-related skin tumors increased significantly and more steeply than did those of other skin malignancies.
"Cutaneous melanoma is a cause of concern for those involved in cancer control in Europe (de Vries et al, 2003; Hemminki et al, 2003; de Vries and Coebergh, 2004), North America (Jemal et al, 2001; Swetter et al, 2005), and Australasia (Martin and Robinson, 2004; Baade and Coory, 2005; Coory et al, 2006). Data from all three continents show a continuing rise in incidence, although in some countries incidence figures may be stabilising in younger females. "
[Show abstract][Hide abstract] ABSTRACT: We studied 12,450 cases of invasive melanoma diagnosed in Scotland in 1979-2003, by thickness, pathological type, and body site at ages under 40, 40-59, and 60 years and over. Melanoma incidence trebled in males from 3.57 to 10.93/10(5) per year, and increased 2.3-fold in females from 5.60 to 12.96/10(5) per year. The rate of increase fell in each successive 5-year period. The greatest increase was in males aged 60 years and over at diagnosis. Significant incidence increases were seen in melanomas < 1 mm in all three age groups, but those > 4 mm only increased significantly at ages 60 years and over. All histological types increased significantly at ages 60 years and over, and in this age group the greatest increase was seen on the head and neck. Five-year disease-free survival improved steadily. Survival figures for 1994-1998 ranged from 93.6% for males and 95.8% for females with tumours < 1 mm, to 52.4 and 48.3%, respectively, for those with tumours > 4 mm. Over the 25 years, melanoma mortality doubled in males from 1.1 to 2.4/10(5) per year, but was unchanged in females at 1.5/10(5) per year. Public education on melanoma is required both for primary prevention and earlier diagnosis, particularly for older males.
British Journal of Cancer 06/2007; 96(11):1772-7. DOI:10.1038/sj.bjc.6603801 · 4.84 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: ■ Conjunctival melanoma is very rare, but occurs more frequently in white than in black individuals
■ Conjunctival melanoma often occurs in the setting of primary acquired melanosis (PAM) with atypia and is less often associated
with a conjunctival nevus
■ Conjunctival melanoma shares many clinical, epidemiological and molecular features with cutaneous but not uveal melanoma
■ It is plausible that the presence of clinically atypical nevus of the skin (particularly when in a familial setting and
in association with cutaneous melanoma) is etiologically linked to conjunctival melanoma
■ There is substantial evidence implicating ultraviolet radiation (UVR) as inducing conjunctival melanoma, probably through
the mitogen-activated protein kinase pathway
■ Because conjunctival melanoma occasionally arises in parts of the conjunctiva protected from UVR exposure, alternative pathways
Myrella Vlenterie, Vincent K Y Ho, Suzanne E J Kaal, Richelle Vlenterie, Rick Haas, Winette T A van der Graaf,
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