"While immunocompetent individuals may not even need treatment for CSD, it is generally recommended that those with immunodeficiency states such as AIDS and transplantation received prolonged courses (at least 3 months) of antimicrobial therapy.16 Short courses of therapy that may suffice in otherwise healthy hosts may not be adequate in transplant recipients. "
[Show abstract][Hide abstract] ABSTRACT: Cat scratch disease has been reported very rarely in cardiac transplant recipients. In a review of 1073 episodes of infection in 620 heart transplant patients over a 16 year period, only one case of infection secondary to Bartonella henselae was documented. Another case of hepatosplenic bacillary angiomatosis from B. henselae was reported 2 decades ago in a heart transplant recipient who had presented with fevers of unknown origin. Although the typical clinical manifestation is that of a skin lesion accompanied with lymphadenopathy, cat scratch disease may present with persistent fevers without a clinically overt infective focus in immunosuppressed individuals. Moreover, more than one disease process may coexist in immunocompromised hosts. While the lymphadenopathy in our patient was secondary to Cat scratch disease, interestingly, the adjacent skin lesion that was thought to represent unhealed site of inoculation of Bartonella was diagnosed as squamous cell carcinoma.
[Show abstract][Hide abstract] ABSTRACT: La survenue d'adénopathies chez un patient traité par anti-TNF-α fait redouter l'existence d'une tuberculose ganglionnaire ou d'une hémopathie. La mise en évidence d'une réaction granulomateuse oriente vers une tuberculose. De nombreuses autres infections responsables d'une réaction granulomateuse ont été rapportées chez les patients traités par anti-TNF-α. Nous rapportons une observation où des adénopathies granulomateuses chez un patient traité par étanercept pour une spondylarthrite ankylosante étaient secondaires à une infection à Bartonella henselae.
Revue du Rhumatisme 03/2007; 74(3):283-285. DOI:10.1016/j.rhum.2006.05.028
[Show abstract][Hide abstract] ABSTRACT: Numerous reports exist of the transmission of zoonoses to humans during and after solid-organ and hematopoietic stem cell transplantation. Donor-derived infections of numerous etiologies, including West Nile virus infection, Chagas disease, toxoplasmosis, rabies, lymphocytic choriomeningitis virus infection, and infection due to Brucella species have been reported. Most zoonoses occur as a primary infection after transplantation, and immunocompromised patients are more likely to experience significant morbidity and mortality from these infections. Risks of zoonotic infection in the posttransplantation period could be reduced by patient education. Increased recognition of the risks of zoonoses, as well as the advent of molecular biology-based testing, will potentially augment diagnostic aptitude. Documented zoonotic infection as it affects transplantation will be the primary focus of this review.
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