Infantile bilateral striatal necrosis associated with human herpes virus-6 (HHV-6) infection.
ABSTRACT A 1-year-old female with acute bilateral striatal necrosis secondary to exanthema subitum associated with human herpesvirus 6 (HHV-6) infection is reported. The patient was previously healthy. She presented with progressive neurologic signs of oral dyskinesia and involuntary movements, after suffering from exanthema subitum. Initial magnetic resonance imaging (MRI) demonstrated abnormal signals in the bilateral striatal regions. In addition, the serum HHV-6 IgM class antibody level was significantly increased. The patient is thought to be the first case of HHV-6 infection related infantile bilateral striatal necrosis (IBSN).
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ABSTRACT: OBJECTIVE: The aim of this article is to review systemic manifestations of human herpes virus 6 (HHV-6) associated diseases in immunocompromised patients. CONCLUSION: The spectrum of HHV-6 associated disorders is broad, but radiologists are frequently not familiar with these disorders. In the clinical setting of acute infection in an immunocompromised patient, the presence of one of these findings (e.g., limbic encephalitis; atypical interstitial pneumonia; pericarditis or myocarditis; or, less commonly, gastrointestinal or hepatobiliary disorders) should raise the suspicion of a possible HHV-6 related complication.American Journal of Roentgenology 11/2009; 193(5):W373-80. · 2.78 Impact Factor