Article

Infantile bilateral striatal necrosis associated with human herpes virus-6 (HHV-6) infection.

Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi-Horikoji, Kamigyo, Kyoto 602-8566, Japan.
Brain and Development (impact factor: 2.12). 11/2005; 27(7):527-30. DOI:10.1016/j.braindev.2004.12.004 pp.527-30
Source: PubMed

ABSTRACT A 1-year-old female with acute bilateral striatal necrosis secondary to exanthema subitum associated with human herpesvirus 6 (HHV-6) infection is reported. The patient was previously healthy. She presented with progressive neurologic signs of oral dyskinesia and involuntary movements, after suffering from exanthema subitum. Initial magnetic resonance imaging (MRI) demonstrated abnormal signals in the bilateral striatal regions. In addition, the serum HHV-6 IgM class antibody level was significantly increased. The patient is thought to be the first case of HHV-6 infection related infantile bilateral striatal necrosis (IBSN).

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Keywords

1-year-old female
 
acute bilateral striatal necrosis secondary
 
bilateral striatal regions
 
HHV-6
 
HHV-6 infection
 
human herpesvirus 6
 
infantile bilateral striatal necrosis
 
Initial magnetic resonance imaging
 
involuntary movements
 
oral dyskinesia
 
progressive neurologic signs
 
serum HHV-6 IgM class antibody level
 

Aki Murakami