Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin
ABSTRACT Chronic exposure of the skin to sunlight causes damage to the underlying connective tissue with a loss of elasticity and firmness. Silicon (Si) was suggested to have an important function in the formation and maintenance of connective tissue. Choline-stabilized orthosilicic acid ("ch-OSA") is a bioavailable form of silicon which was found to increase the hydroxyproline concentration in the dermis of animals. The effect of ch-OSA on skin, nails and hair was investigated in a randomized, double blind, placebo-controlled study. Fifty women with photodamaged facial skin were administered orally during 20 weeks, 10 mg Si/day in the form of ch-OSA pellets (n=25) or a placebo (n=25). Noninvasive methods were used to evaluate skin microrelief (forearm), hydration (forearm) and mechanical anisotropy (forehead). Volunteers evaluated on a virtual analog scale (VAS, "none=0, severe=3") brittleness of hair and nails. The serum Si concentration was significantly higher after a 20-week supplementation in subjects with ch-OSA compared to the placebo group. Skin roughness parameters increased in the placebo group (Rt:+8%; Rm: +11%; Rz: +6%) but decreased in the ch-OSA group (Rt: -16%; Rm: -19%; Rz: -8%). The change in roughness from baseline was significantly different between ch-OSA and placebo groups for Rt and Rm. The difference in longitudinal and lateral shear propagation time increased after 20 weeks in the placebo group but decreased in the ch-OSA group suggesting improvement in isotropy of the skin. VAS scores for nail and hair brittleness were significantly lower after 20 weeks in the ch-OSA group compared to baseline scores. Oral intake of ch-OSA during the 20 weeks results in a significant positive effect on skin surface and skin mechanical properties, and on brittleness of hair and nails.
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ABSTRACT: Silicon is a trace element for humans, and is absorbed from food in the form of orthosilicic acid. Instant food products are part of a constantly growing market of convenience foods, which have not been evaluated yet as sources of silicon. In this study the total and soluble silicon contents in different instant food products were determined by using graphite furnace atomic absorption spectrometry (GF-AAS). A selection of instant products commercially available in Wroclaw were analyzed: soups, main courses, coffee drinks, jellies and puddings. Total silicon contents in soups, main courses and coffee drinks ranged widely and reached the values: 0.10-30.20, 0.63-37.91 and 0.21-13.37mg/serving, respectively. These products contained 0.05-1.26mg of soluble silicon per serving. The total silicon content in jellies and puddings did not exceed 0.36mg and 2.42mg/serving, respectively. Among the analyzed desserts the highest level of soluble silicon was found in chocolate puddings: 0.36-0.41mg/serving. The silicon level in servings of the studied instant products when prepared with the appropriate amount of water was also estimated. The mean content of silicon determined in samples of drinking water from Wrocław and the vicinity, which was used for the estimation, amounted to 7.09mg/l. The total silicon content in ready-to-eat products ranged from 1.32 to 39.21mg/serving. In conclusion, some of the analyzed instant foods contained very high amounts of silicon, however the content of the soluble, and hence available, form of this element was low.Food Chemistry 12/2012; 135(3):1756-61. DOI:10.1016/j.foodchem.2012.05.105 · 3.26 Impact Factor
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ABSTRACT: Background. Silicon, the third most abundant trace element of the human body, is listed as an essential one. It is especially associated with connective tissues as it has been found to take part in bone development, collagen formation and mineralization of bone matrix. Silicon is also implicated in mammalian hormonal control and in protecting against heart disease in humans. Objectives. The influence of different doses of orally-administered silicon on calcium and magnesium concentrations in the blood of experimental animals was evaluated. Material and Methods. The experiment was carried out on male Wistar rats. A control group was given distilled water to drink. The rats in group 0 were given a solution of sodium hydroxide (0.001 mol/L), whereas animals in groups 1, 2 and 3 received solutions of orthosilicic acid of three different concentrations (0.05%, 0.5% and 1%) as the only drinking fluids. Blood was collected after 4 and then 8 weeks of the experiment. Determination of calcium and magnesium concentrations in the blood was performed by the ICP-AES method. Results. Silicon administration caused an increase in blood calcium concentration after 4 as well as after 8 weeks of the experiment. Four-week-long silicon intoxication caused a decrease in blood magnesium concentrations, whereas an increase in blood magnesium level in groups 0, 1 and 3 and a decrease in group 2 after 8 weeks of the experiment were noted. Conclusions. Silicon was found to significantly influence metabolism of calcium and magnesium. Its interaction with calcium during the process of bones mineralization suggests that Si supplementation may be helpful in preventing osteoporosis in postmenopausal women whose calcium intake is insufficient. Homeostasis in mineral metabolism and balance between elements are very important matters, therefore silicon metabolism and its interactions with other elements and nutrients should be further investigated (Adv Clin Exp Med 2011, 20, 6,677–682). Key words: calcium, magnesium, silicon, rats, chronic toxicity.Advances in Clinical and Experimental Medicine 01/2011; 20(6):677-682. · 0.09 Impact Factor
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ABSTRACT: Standardized validated evaluation instruments are mandatory to increase the level of evidence in scar management. Scar assessment scales are potentially suitable for this purpose, but the most appropriate scale still needs to be determined. This review will elaborate on several clinically relevant scar features and critically discuss the currently available scar scales in terms of basic clinimetric requirements. Many current scales can produce reliable measurements but seem to require multiple observers to obtain these results reliably, which limits their feasibility in clinical practice. The validation process of scar scales is hindered by the lack of a "gold standard" in subjective scar assessment or other reliable objective instruments which are necessary for a good comparison. The authors conclude that there are scar scales available that can reliably measure scar quality. However, further research may lead to improvement of their clinimetric properties and enhance the level of evidence in scar research worldwide.Journal of burn care & research: official publication of the American Burn Association 01/2012; 33(2):e79-87. DOI:10.1097/BCR.0b013e318239f5dd · 1.55 Impact Factor