Article

[The composition and drug sensitivity of a mycobacterial population in patients with suspected tuberculosis].

Problemy tuberkuleza i bolezneĭ legkikh 02/2005; pp.36-8
Source: PubMed

ABSTRACT By using the diagnostic material (175 sputum samples and 103 bronchoalveolar lavage fluid samples) taken from 39 patients with suspected tuberculous infection during a 2.5-month follow-up, the authors traced the time course of changes in the composition and drug sensitivity of a mycobacterial population to rifampicin. Along with the traditional microbiological studies, the latest molecular biological studies, a TB-BIOCHIP test system (enzyme immunoassay) in particular, were employed to detect the bacterial and L-transformed forms of the causative agent. A molecular biological assay was first developed to detect the drug sensitivity of L-forms of Mycobacterium tuberculosis.

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Keywords

175 sputum samples
 
2.5-month follow-up
 
bacterial
 
causative agent
 
drug sensitivity
 
L-transformed forms
 
latest molecular biological studies
 
mycobacterial population
 
Mycobacterium tuberculosis
 
TB-BIOCHIP test system
 
time course