Dietary prebiotic oligosaccharides are detectable in the faeces of formula-fed infants. Acta Paediatr

Centre for Infant Nutrition, Macedonio Melloni Maternity Hospital, Milan, Italy.
Acta paediatrica (Oslo, Norway: 1992). Supplement 10/2005; 94(449):27-30. DOI: 10.1080/08035320510043510
Source: PubMed


Human milk oligosaccharides are not digested during intestinal passage and can be detected in stools. In this study it was investigated whether a prebiotic mixture of low-molecular-weight galacto-oligosaccharides (GOS) and high-molecular-weight fructo-oligosaccharides (FOS) can be detected in stool samples of formula-fed infants. The test formula was supplemented with 0.8 g/dl oligosaccharides (GOS+FOS). In the control formula, maltodextrins were used as placebo. Fecal flora was assessed at the beginning (day 1) and at the end of a 28-d feeding period (day 2). At day 2 the content of galacto- and fructo-oligosaccharides in the stool samples were measured. On study day 1, the number of bifidobacteria was not different among the groups (supplemented group: 7.7 (6.2) CFU/g; placebo group: 8.0 (6.0) CFU/g). At the end of the 28-d feeding period, the number of bifidobacteria was significantly higher in the group fed the supplemented formula when compared to placebo (supplemented group: 9.8 (0.7) CFU/g stool; placebo group: 7.1 (4.7) CFU/g stool; p<0.001). In all infants fed the supplemented formula, GOS and FOS could be identified in the stool samples. That was not the case in infants fed the non-supplemented formula.
Conclusion: The present data confirm the bifidogenicity of oligosaccharides and indicate that dietary galacto-oligosaccharides and long chain fructo-oligosaccharides remain during the whole passage in the lumen of the gastrointestinal tract, similarly to human milk oligosaccharides.

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    • "Moro 2003 [75] Full Term None/Not clear Mohan 2006 [76] Pre-Term None/Not clear Moro 2005 [77] Full Term None/Not clear Reuman1986 [78] Pre-Term None/Not clear Moro 2006 [79] Arslanoglu 2007 [80] Arslanoglu 2008 [81] Van Hoffen 2009 [82] Schouten 2011 [83] Full Term Numico Riskin 2009 [84] Pre-Term None/Not clear Piemontese 2011 [85] Full Term Danone Rouge 2009 [86] Pre-Term French Ministry of Health "
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    • "The results for each study are therefore reported separately. Four studies showed that prebiotics significantly increased bifidobacteria: Fanaro 2005 [42] (MD 0.30, 95% CI: 0.13 to 0.47, n = 46); Moro 2005 [47] (MD 2.70, 95% CI: 0.37 to 5.03, n = 32); Xiao-Ming 2004 [53] (MD 1.90, 95% CI: 1.51 to 2.29, n = 121); Xiao-Ming 2008 [54] (MD 0.85, 95% CI: 0.16 to 1.54, n = 38). The prebiotic results for the two types of prebiotics (acidic oligosaccharides with maltodextrin or neutral GOS FOS) in Fanaro 2005 [42] were combined before meta-analysis using combined mean and pooled SD. "
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