[Biomaterials and tissues material in the treatment of prosthetic grafts infections].

Katedra i Klinika Chirurgii, Naczyniowej, Ogólnej i Transplantacyjnej Akademii Medycznej we Wrocławiu.
Polimery w medycynie 02/2005; 35(2):41-7.
Source: PubMed


An article is presented the treatment of vascular prosthetic grafts infections. An the graft infection treated by the replacement of infected prosthesis with autogenic venous material or with venous and arterial allograft harvested from brain-dead organ donors together with multiple organ procurement is presented. Autogenous material has an ability a better healing in infected tissues and used with absorbable sutures may lead to complete recovery from vascular graft infection - a severe and often lethal complication. An article is presented the treatment of vascular prosthetic grafts infections with the use of more resistant prostheses of infection - silver coated prosthesis, prosthesis with antibiotic and polytetrafluoroethylene prostheses.

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    ABSTRACT: The purpose of this study is to determine the effect of silver coating of polypropylene implants on infection in hernia surgery. Silver-coated and non-silver-coated large pore monofilament polypropylene mesh implants were compared with and without infection (four groups). The implants were inserted in the abdominal wall of female Wistar rats. An Escherichia coli strain was inoculated intraoperatively in the two infected groups. The implants were removed, and clinical, bacteriological, and histological analyses were performed at 2, 15, and 30 days postoperatively. Eighty-four rats were studied. All inoculated rats (n = 21) in the non-silver-coated polypropylene group presented periprosthetic E. coli infection, compared with only five inoculated rats in the silver-coated polypropylene group (p < 0.0001). Erosion was significantly higher in the infected than in the non-infected silver-coated polypropylene groups (p < 0.01). There was no histological difference between the four groups. Silver-coated implants appear effective against bacterial infection in our rat model, with good histological tolerance but delayed healing.
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