Does the addition of cognitive behavioral therapy improve panic disorder treatment outcome relative to medication alone in the primary-care setting?

Department of Psychology, University of California-Los Angeles, 405 Holgard Avenue, Los Angeles, CA 90095, USA.
Psychological Medicine (Impact Factor: 5.43). 12/2005; 35(11):1645-54. DOI: 10.1017/S003329170500557X
Source: PubMed

ABSTRACT Randomized clinical trials indicate a benefit from combining medications with cognitive behavioral therapy (CBT) relative to medication alone for panic disorder. Using an as-treated analysis, we evaluated whether the addition of CBT enhanced outcomes for panic disorder relative to medications alone in the primary-care setting.
Primary-care patients with panic disorder reported on their receipt of CBT and medications over the 3 months following baseline assessment. The degree to which outcomes for those who used anti-panic medications were enhanced by the receipt of at least one component of CBT was analyzed using a propensity score model that took into account observable baseline patient characteristics influencing both treatment selection and outcomes.
The addition of CBT resulted in statistically and clinically significant improvements at 3 months on anxiety sensitivity, social avoidance, and disability. Also, patients receiving CBT in the first 3 months of the study were more improved at 12 months than patients who took medications only during the first 3 months of the study.
The clinical utility of the findings are discussed in terms of the importance of primary-care physicians encouraging their panic disorder patients to receive CBT as well as medications.

1 Follower
  • Source
    Psychological Science in the Public Interest 11/2008; DOI:10.1111/j.1539-6053.2009.01035.x
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective.-To examine the impact of common mental illness on functional disability and the cross-cultural consistency of this relationship while controlling for physical illness. A secondary objective was to determine the level of disability associated with specific psychiatric disorders. Design.-A cross-sectional sample selected by two-stage sampling. Setting.-Primary health care facilities in 14 countries covering most major cultures and languages. Patients.-A total of 25916 consecutive attenders of these facilities were screened for psychopathology using the General Health Questionnaire (96% response). Screened patients were sampled from the General Health Questionnaire score strata for the second-stage Composite International Diagnostic Interview administered to 5447 patients (62% response). Main outcome Measures.-Patient-reported physical disability, number of disability days, and interviewer-rated occupational role functioning. Results.-After controlling for physical disease severity, psychopathology was consistently associated with increased disability. Physical disease severity was an independent, although weaker, contributor to disability. A dose-response relationship was found between severity of mental illness and disability. Disability was most prominent among patients with major depression, panic disorder, generalized anxiety, and neurasthenia; disorder-specific differences were modest after controlling for psychiatric comorbidity. Results were consistent across disability measures and across centers. Conclusions. The consistent relationship of psychopathology and disability indicates the compelling personal and socioeconomic impact of common mental illnesses across cultures. This suggests the importance of impairments of higher-order human capacities (eg, emotion, motivation, and cognition) as determinants of functional disability
    JAMA The Journal of the American Medical Association 12/1994; 272(22-22):1741-1748. DOI:10.1001/jama.272.22.1741 · 30.39 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: In this paper, we present a client with panic disorder and agoraphobia who relapses following a full course of cognitive behavioral therapy (CBT). To frame the client's treatment, the major components of CBT for panic disorder with or without agoraphobia (PD/A) are reviewed. Likely reasons for the treatment's failure and strategies for improving treatment are explored from the perspective of basic research on learning and memory. Treatment recommendations primarily focus on enhancing the exposure component of PD/A treatment but include suggestions for enhancing other CBT components as well.
    Cognitive and Behavioral Practice 08/2011; 18(3):306-315. DOI:10.1016/j.cbpra.2010.05.006 · 1.33 Impact Factor