5-day nonobserved artesunate monotherapy for treating uncomplicated Falciparum malaria in young Gabonese children.

Medical Research Unit, Albert Schweitzer Hospital Lambaréné, Gabon.
The American journal of tropical medicine and hygiene (Impact Factor: 2.74). 11/2005; 73(4):705-9.
Source: PubMed

ABSTRACT Despite different recommendations from WHO and national authorities, artesunate monotherapy is increasingly used for treating African children with malaria. A 5-day course of oral artesunate (first day: 4 mg/kg body weight, observed intake; and 2 mg/kg body weight on the following days with nonobserved drug intake) yielded a PCR-corrected Day 28 cure rate of 90% (45 of 50 patients; CI 78-97%) in Gabonese children aged between 2 and 18 months. Artesunate was well tolerated, and no severe adverse events were reported.

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Available from: Norbert Georg Schwarz, Aug 12, 2015
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