Prescribing methadone as an analgesic [8]

Annals of internal medicine (Impact Factor: 17.81). 11/2005; 143(8):620. DOI: 10.7326/0003-4819-143-8-200510180-00028
Source: PubMed
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    • "If withdrawal symptoms are not suppressed within 1 hour, more can be given, but in general the initial dose should not exceed 30 mg, and the total 24hour dose should not exceed 40 mg the first few days. In a nontolerant individual, an initial tolerated dose can become risky if continued beyond 2 days because of rising methadone blood levels.8 The clinician should be alert for signs of drowsiness or motor impairment. "
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