Olanzapine in treatment of patients with bipolar 1 disorder and panic comorbidity: a case study.

Psychiatric Clinic, Clinical Centre University of Sarajevo.
Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences (Impact Factor: 0.44). 12/2003; 3(4):67-9.
Source: PubMed


Anxiety disorders are frequently co-morbid with bipolar disorders (BP). Anxiety symptoms can have a great impact on course of illness and patient's quality of life. Olanzapine is the first antipsychotic approved as a mood stabilizing agent. In this paper two cases of BP 1 disorder where panic attacks co-occur treated with olanzapine were presented. In both cases olanzapine showed very good effects in treatment of panic symptoms within the course of BP disorder.

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    ABSTRACT: Mood disorders in general, and bipolar disorder in particular, are unique among the psychiatric conditions in that they are associated with extraordinarily high rates of comorbidity with a multitude of psychiatric and medical conditions. Among all the potential comorbidities, co-occurring anxiety disorders stand out due to their very high prevalence. Outcome in bipolar illness is worse in the presence of a comorbid anxiety disorder. The coexistence of an anxiety disorder presents a particularly difficult challenge in the treatment of bipolar illness since antidepressants, the mainstay of pharmacologic treatments for anxiety, may adversely alter the course of manic-depression. Identification of anxiety disorders in bipolar patients is important. The treatment plan needs to balance the potential benefit and harm of antidepressant administration.
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